Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
As UCP1-enriched cells can consume lipids by generating heat, browning of white adipocytes is now highlighted as a promising approach for the prevention of obesity and obesity-associated metabolic diseases.
|
30132867 |
2019 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Brown adipose tissue (BAT) with its thermogenic function due to the presence of the mitochondrial uncoupling protein 1 (UCP1), has been positively associated with improved resistance to obesity and metabolic diseases.
|
30687113 |
2018 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The induction of brown-like adipocytes in white adipose tissue (WAT) is a potential therapeutic target for the treatment of obesity and metabolic disorders via the ability of these cells to release excess energy as heat in association with uncoupling protein 1.
|
29334590 |
2018 |
Metabolic Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The aim of the study was to determine transcriptional levels of UCP1 and UCP2 in peripheral blood mononuclear cells (PBMCs) from patients with metabolic disorders: T2DM, obesity and from healthy individuals.
|
29151065 |
2017 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, RSE alleviated metabolic disorders in HF-diet-fed C57BL/6 mice by potentially activating UCP and PPAR signaling.
|
28507819 |
2017 |
Metabolic Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We investigated whether or not the UCP1 -3826 A>G polymorphism is associated with obesity and related metabolic disorders in grade III obese patients.
|
26458326 |
2016 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, the aim of this study was to review the role of UCP1 in the development of these metabolic diseases.
|
22790465 |
2012 |
Metabolic Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Uncoupling protein-1 (UCP-1), which plays a major role in thermogenesis and energy expenditure can increase the risk of obesity and can be related metabolic disorders.
|
23043591 |
2012 |
Metabolic Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A-3826G polymorphism within the promoter region of the uncoupling protein-1 (UCP-1) gene is possibly involved in the pathophysiology of obesity and metabolic disorders.
|
18068010 |
2008 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders.
|
15281018 |
2004 |
Metabolic Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland.
|
12375583 |
2002 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Very recently, the cloning of UCP2 and UCP3, two homologues of UCP1, has renewed the field of research on the importance of respiration control in metabolic processes and metabolic diseases.
|
10395193 |
1999 |
Metabolic Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The recently described A-->G (-3826) point mutation within the distal region of the UCP-1 promoter is possibly involved in the development of obesity, diabetes and related metabolic disorders.
|
10469165 |
1999 |