|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Publisher Correction: Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle.
|
30862953 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Using murine intestinal cancer models and CRC patient samples, we find higher UCP2 protein levels in tumors compared to their non-tumoral counterparts.
|
31461648 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In mice, administration of Bou (50 mg/kg) also suppressed the growth of rectal cancer associated with increases the UCP2 expression and mitochondria capacity in the tumor.
|
31028741 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The present review summarizes the latest findings of UCP2 with respect to obesity, diabetes and cancer.
|
31330574 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.070 |
Biomarker
|
disease |
BEFREE |
Computational metabolic modelling highlighted functional relevance of PNPLA3, GCKR and UCP2 for NAFLD development.
|
30444569 |
2019 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
The UCP2 upregulation is positively correlated with enhanced proliferation, tumorigenesis, and metabolic alterations, thus suggesting that UCP2 upregulation can play a key role in sensing metabolic changes to promote tumorigenesis.
|
30556651 |
2019 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
We reveal the tumor-suppressive role of UCP2 as its deletion enhances colon and small intestinal tumorigenesis in AOM/DSS-treated and Apc<sup>Min/+</sup> mice, respectively, and correlates with poor survival in the latter model.
|
31461648 |
2019 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Uncoupling protein 2 (UCP2) is upregulated in several human cancers which contributes to tumorigenesis.
|
31085159 |
2019 |
|
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
The DEGs such as SFRP1, MMP7, CDH1, FAS, and UCP2 might be the potential biomarkers in breast cancer.
|
30446971 |
2019 |
|
Diabetic Retinopathy
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our group previously showed that the UCP2 -866A allele was associated with risk of diabetic retinopathy (DR), which is caused by hyperglycemia-induced oxidative stress.
|
31218541 |
2019 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
The DEGs such as SFRP1, MMP7, CDH1, FAS, and UCP2 might be the potential biomarkers in breast cancer.
|
30446971 |
2019 |
|
Diabetic Nephropathy
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
For meta-analysis, a literature search was conducted to identify all studies that investigated associations between UCP2 polymorphisms and DKD in patients with T1DM or type 2 diabetes mellitus.
|
31479096 |
2019 |
|
Diabetic Nephropathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
miRNA-214 suppresses oxidative stress in diabetic nephropathy via the ROS/Akt/mTOR signaling pathway and uncoupling protein 2.
|
30988734 |
2019 |
|
Diabetic Nephropathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2.
|
30345618 |
2019 |
|
Kidney Failure, Acute
|
0.050 |
Biomarker
|
disease |
BEFREE |
Taken together, our results indicate that UCP2 is protective against AKI and suggest that enhancing UCP2 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury.
|
30426490 |
2019 |
|
Kidney Failure, Acute
|
0.050 |
Biomarker
|
disease |
BEFREE |
UCP2 alleviates tubular epithelial cell apoptosis in lipopolysaccharide-induced acute kidney injury by decreasing ROS production.
|
31071510 |
2019 |
|
Kidney Failure, Acute
|
0.050 |
Biomarker
|
disease |
BEFREE |
In vitro, UCP2 overexpression or knockdown was achieved by LV5-UCP2 or si-UCP2 transfection, respectively, to characterize the mechanisms of UCP2 in septic AKI.
|
30952098 |
2019 |
|
Septicemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
The present study was designed to determine whether UCP2 has a protective effect in an experimental sepsis model in astrocytes asnd to clarify the mechanisms responsible for its neuroprotective effects after sepsis.
|
31702042 |
2019 |
|
Sepsis
|
0.050 |
Biomarker
|
disease |
BEFREE |
The present study was designed to determine whether UCP2 has a protective effect in an experimental sepsis model in astrocytes asnd to clarify the mechanisms responsible for its neuroprotective effects after sepsis.
|
31702042 |
2019 |
|
Neurodegenerative Disorders
|
0.040 |
Biomarker
|
group |
BEFREE |
The mitochondrial uncoupling protein 2 (UCP2) relieves oxidative and neuronal damage in a variety of neurodegenerative disease models.
|
30814312 |
2019 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We show that UCP2 loss renders colon cells more prone to malignant transformation through metabolic reprogramming and perturbation of redox homeostasis and could favor worse outcomes in CRC.
|
31461648 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
For meta-analysis, a literature search was conducted to identify all studies that investigated associations between UCP2 polymorphisms and DKD in patients with T1DM or type 2 diabetes mellitus.
|
31479096 |
2019 |
|
Arthritis, Psoriatic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Additionally, 1,25(OH)2D significantly increased ATP levels and gene expression related to mitochondrial function such as carnitine palmitoyltransferase 1 (CPT1), peroxisome proliferator-activated receptor α (PPARα), very long-chain acyl-CoA dehydrogenase (VLCAD), long-chain acyl-CoA dehydrogenase (LCAD), medium-chain acyl-CoA dehydrogenase (MCAD), uncoupling protein 2 (UCP2), and UCP3 and the vitamin D pathway including 25-dihydroxyvitamin D3 24-hydroxylase (CYP24) and 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27) in PA-treated C2C12 myotubes.
|
31744213 |
2019 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally we show, using either a genetic or pharmacological approach, that induction of UCP2 sensitizes melanomas to programmed cell death protein-1 blockade treatment and elicits effective anti-tumor responses.
|
30664764 |
2019 |
|
Malignant transformation
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We show that UCP2 loss renders colon cells more prone to malignant transformation through metabolic reprogramming and perturbation of redox homeostasis and could favor worse outcomes in CRC.
|
31461648 |
2019 |