UCP2, uncoupling protein 2, 7351

N. diseases: 235; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.370 Biomarker disease BEFREE Finally, UCP2 maps to regions of human chromosome 11 and mouse chromosome 7 that have been linked to hyperinsulinaemia and obesity. 9054939 1997
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity. 9054939 1997
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.100 Biomarker group BEFREE We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity. 9054939 1997
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance. 9349606 1997
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.370 Biomarker disease BEFREE The murine UCP2 was mapped to a region on mouse chromosome 7 which in several models has been shown to be linked to obesity and hyperinsulinaemia. 9349606 1997
CUI: C0271638
Disease: Type 2 diabetes mellitus in obese
Type 2 diabetes mellitus in obese 		0.010 GeneticVariation disease BEFREE We conclude that genetic variability in the human UCP2 gene is not a common factor contributing to NIDDM in obese Danish Caucasian subjects and the common A/V55 amino acid polymorphism of the gene is not implicated in the pathogenesis of juvenile or maturity onset obesity or insulin resistance in Caucasians. 9349606 1997
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE Human UCP3 is different from UCP1 and UCP2 by its high and preferential expression in skeletal muscle and consequently the UCP3 gene is an attractive candidate gene for obesity. 9498661 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE The UCP2-UCP3 gene cluster maps to chromosome 11q13 in humans, and polymorphisms in these genes may contribute to obesity through effects on energy metabolism. 9700198 1998
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 GeneticVariation disease BEFREE These results indicate that the Ala55 --> Val and Ala232 --> Thr variants of UCP2 do not play an important role in the pathogenesis of NIDDM or obesity in the Japanese population. 9709950 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE These results indicate that the Ala55 --> Val and Ala232 --> Thr variants of UCP2 do not play an important role in the pathogenesis of NIDDM or obesity in the Japanese population. 9709950 1998
CUI: C0451819
Disease: Simple obesity
Simple obesity 		0.010 GeneticVariation disease BEFREE With the use of this sequence information, 25 Japanese patients with obesity and noninsulin-dependent diabetes mellitus (NIDDM) and 25 subjects with simple obesity were screened for mutations in the entire coding region of UCP2 by PCR and single-strand conformation polymorphism analysis. 9709950 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE Since a decreased basal metabolic rate (BMR) would increase the susceptibility to weight gain, genetic alterations in the UCP2 gene could contribute to the pathogenesis of obesity and the metabolic syndrome (MSDR). 9724080 1998
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.080 Biomarker disease BEFREE No association was found between the UCP2 gene and BMR in patients with MSDR or in healthy controls. 9724080 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE The aim of this study was to investigate whether obesity is accompanied by aberrations in UCP2 and UCP3 regulation. 9726596 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE These data support the concept that impaired adipose tissue expression of UCP2 may play a role in the pathophysiology of obesity. 9726597 1998
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 AlteredExpression disease BEFREE We conclude that 1) skeletal muscle mRNA levels encoding UCP2 and UCP3 are correlated among individuals and may be coordinately regulated; 2) UCP3 expression is not regulated by differential effects on UCP3L and UCP3S forms of the mRNA; and 3) UCP mRNA expression tends to increase in muscle as a function of obesity but not of resting metabolic rate or insulin resistance, and is increased in patients with type 2 diabetes. 9836527 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE We conclude that 1) skeletal muscle mRNA levels encoding UCP2 and UCP3 are correlated among individuals and may be coordinately regulated; 2) UCP3 expression is not regulated by differential effects on UCP3L and UCP3S forms of the mRNA; and 3) UCP mRNA expression tends to increase in muscle as a function of obesity but not of resting metabolic rate or insulin resistance, and is increased in patients with type 2 diabetes. 9836527 1998
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.040 AlteredExpression disease BEFREE Our results indicate that UCP2 is expressed in some hepatocarcinoma cell lines and that serum components may participate in maintaining elevated UCP2 levels. 9849876 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE From the three different human UCPs identified so far by gene cloning both UCP2 and UCP3 were mapped in close proximity (75-150 kb) to regions of human chromosome 11 (11q13) that have been linked to obesity and hyperinsulinaemia. 10027754 1999
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.370 Biomarker disease BEFREE From the three different human UCPs identified so far by gene cloning both UCP2 and UCP3 were mapped in close proximity (75-150 kb) to regions of human chromosome 11 (11q13) that have been linked to obesity and hyperinsulinaemia. 10027754 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE The data suggest that it is not a reduction in UCP2 or UCP3 expression that causes obesity in the susceptible mice. 10066417 1999
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.030 GeneticVariation disease BEFREE Association between a marker in the UCP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa. 10089012 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE In contrast, UCP2 mRNA levels were increased by 30% in skeletal muscle of 20% weight-reduced subjects with obesity. 10102249 1999
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 GeneticVariation disease BEFREE Screening for variants of the uncoupling protein 2 gene in Japanese patients with non-insulin-dependent diabetes mellitus. 10337857 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE Genetic mutations of UCP2 may not be commonly associated with obesity or diabetes in Japanese subjects. 10337857 1999