IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we evaluated the influence of the G38A polymorphism in the CC16 gene exon 1 on the development and progression of IgAN.
|
17338426 |
2007 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, a single nucleotide polymorphism in the UG gene (A38G) has been associated with rapid progression of human IgAN.
|
16703373 |
2006 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
There also was no significant association between uteroglobin AA genotype or A allele and IgA nephropathy progression (OR, 3.62; 95% CI, 0.59 to 22.34; OR, 2.19, 95% CI, 0.37 to 13.14, respectively).
|
16797381 |
2006 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Traditionally, the case-control study design was employed to identify associations between particular candidate genes, for example, HLA antigens the uteroglobin gene and IgAN, giving conflicting results.
|
12768083 |
2003 |
IGA Glomerulonephritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Levels of UG binding to Fn were similar in patients with IgA nephropathy and healthy controls.
|
12200800 |
2002 |
IGA Glomerulonephritis
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Levels of UG binding to Fn were similar in patients with IgA nephropathy and healthy controls.
|
12200800 |
2002 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To detect the presence of polymorphisms in the UG coding sequence, the DNA of 109 patients with IgA nephropathy (IgAN), and 32 patients with systemic lupus erythematosus (SLE) were tested for the nucleotide sequence of all three UG exons by heteroduplex analysis.
|
12003994 |
2002 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A genetic polymorphism in uteroglobin has been reported to be associated with progression of IgA nephropathy in a Caucasian population, but the findings remain controversial.
|
11967037 |
2002 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
A genetic polymorphism in uteroglobin has been reported to be associated with progression of IgA nephropathy in a Caucasian population, but the findings remain controversial.
|
11967037 |
2002 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
We analyzed the UG gene as a candidate for a predisposing factor in 61 Japanese patients with IgA nephropathy (23 children, 38 adults) and detected only the G38A mutation.
|
11774099 |
2002 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the UG gene as a candidate for a predisposing factor in 61 Japanese patients with IgA nephropathy (23 children, 38 adults) and detected only the G38A mutation.
|
11774099 |
2002 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We speculated that the single nucleotide polymorphism at the 38th nucleotide (A to G) from the transcription initiation site of UG exon 1 would impact the progression of IgA nephropathy (IgAN).
|
11434507 |
2001 |
IGA Glomerulonephritis
|
0.300 |
Biomarker
|
disease |
MGD |
Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein.
|
11045570 |
2000 |
IGA Glomerulonephritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We review here the evidence for genetic factors in the development and progression of IgAN, including a reappraisal of earlier conflicting results from small immunogenetic case-control studies, the evidence for racial differences in the prevalence of IgAN, a detailed summary of all reported occurrences of familial IgAN worldwide, and an exhaustive review of new insights gained through the study of two murine models of hereditary IgAN: the ddY and the uteroglobin-deficient mouse.
|
10792601 |
2000 |
IGA Glomerulonephritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We performed an association study of patients with IgA nephropathy and matching control subjects to test whether the G38A polymorphism in the uteroglobin gene, the C2093T polymorphism in the megsin gene, or the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism is associated with IgA nephropathy or rate of disease progression in patients with IgA nephropathy.
|
10977777 |
2000 |
IGA Glomerulonephritis
|
0.300 |
Biomarker
|
disease |
MGD |
These results define an essential role for UG in preventing mouse IgA nephropathy and warrant further studies to determine if a similar mechanism(s) underlies the human disease.
|
10470078 |
1999 |
IGA Glomerulonephritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results define an essential role for UG in preventing mouse IgA nephropathy and warrant further studies to determine if a similar mechanism(s) underlies the human disease.
|
10470078 |
1999 |
IGA Glomerulonephritis
|
0.300 |
Biomarker
|
disease |
MGD |
Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin.
|
9162006 |
1997 |