Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
It has been indicated that the pathogenic effect of UPP on DR was involved in the increase of ROS generation and NF-κB expression, which associated with the ROS/PARP and NF-κB inflammatory factor pathways.
|
26391545 |
2015 |
Adenoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multiple tumors (e.g., lymphoma, hepatoma and lung adenoma) occurred simultaneously in some UPase deficient mice, but not in wild-type mice raised under the same conditions.
|
26801745 |
2016 |
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, pyrroline-5-carboxylate reductase 2 (PYCR2) and uridine phosphorylase 1 (UPase1) were found to be altered in ESCC.
|
30559182 |
2019 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Subcutaneous injection of AdMDR1-CD::UPP into the xenografts of mice bearing tumors of A2780/Taxol cells could significantly suppress the tumor growth and prolong survival as compared with the group of A2780 cells.
|
17471022 |
2007 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Targeted disruption (-/-) of murine uridine phosphorylase (UPase) disrupted the homeostasis of uridine and increased spontaneous tumorigenesis by more than 3-fold.
|
26801745 |
2016 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The activities of uridine phosphorylase in all tumors used showed no changes in response to IFNalpha or Paclitaxel.
|
12359357 |
2002 |
Neoplasms
|
0.060 |
PosttranslationalModification
|
group |
BEFREE |
The characterization of the promoter region of UPase has indicated a direct regulation of its expression by the tumor suppressor gene p53.
|
12084455 |
2002 |
Secondary malignant neoplasm of liver
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The DPD, OPRT, TP, and UP mRNA levels were significantly higher in liver metastases than in primary tumor (expression in relation to that of beta-actin mRNA: 0.42 vs 0.16, P=0.00053; 1.4 vs 0.92, P=0.016; 23 vs 11, P=0.00014; 0.36 vs 0.25, P=0.0026; respectively).
|
15060742 |
2004 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The DPD, OPRT, TP, and UP mRNA levels were significantly higher in liver metastases than in primary tumor (expression in relation to that of beta-actin mRNA: 0.42 vs 0.16, P=0.00053; 1.4 vs 0.92, P=0.016; 23 vs 11, P=0.00014; 0.36 vs 0.25, P=0.0026; respectively).
|
15060742 |
2004 |
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression levels of UPase and dThdPase are higher in human solid tumors including breast carcinomas than in normal tissues.
|
11807789 |
2002 |
Septicemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expression of S100a8, Upp1, and Mt2a in all three brain regions of young septic rats indicate that these genes may be involved in the first line of response to sepsis in the younger brain.
|
30706174 |
2019 |
Sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expression of S100a8, Upp1, and Mt2a in all three brain regions of young septic rats indicate that these genes may be involved in the first line of response to sepsis in the younger brain.
|
30706174 |
2019 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy.
|
20226755 |
2010 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy.
|
20226755 |
2010 |
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA levels of TS, DPD, OPRT, TP, and UP were measured by real-time quantitative RT-PCR in samples from 23 consecutive patients with both primary colorectal adenocarcinoma and liver metastasis.
|
15060742 |
2004 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear.
|
11401323 |
2001 |
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU.
|
17214321 |
2007 |
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU.
|
17214321 |
2007 |
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
To clarify the correlation between the expression levels of UPase and dThdPase genes and the clinicopathological factors, mRNA levels of these enzymes were examined by RT-PCR in 43 breast carcinomas.
|
11807789 |
2002 |
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate whether UPP activated ROS/PARP and NF-κB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.
|
26391545 |
2015 |
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
To investigate whether UPP activated ROS/PARP and NF-κB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.
|
26391545 |
2015 |
Stomach Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis.
|
17214321 |
2007 |
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Uridine phosphorylase 1 (UPP1) is a protein-coding gene and has been detected that UPP1 was the higher expression in many solid malignancies, just as head and neck cancers, breast cancer, compared with paired normal tissue.
|
31496029 |
2019 |
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Uridine phosphorylase 1 (UPP1) is a protein-coding gene and has been detected that UPP1 was the higher expression in many solid malignancies, just as head and neck cancers, breast cancer, compared with paired normal tissue.
|
31496029 |
2019 |
Mouth Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.
|
12115385 |
2002 |