Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 GeneticVariation group BEFREE Adhesion molecules, including soluble E-selectin (sE-selectin), intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1), are associated with incident CVD. 30653588 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression group BEFREE We assessed each participants for typical risk factors of cardiovascular diseases and measured serum levels of vascular cell adhesion molecule-1 (VCAM-1), interleukin 6 (IL-6), and thrombomodulin. 30132147 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group BEFREE Preventing adipocyte derived EV-induced VCAM-1 upregulation may offer a novel therapeutic target in the prevention of obesity-driven cardiovascular disease. 30771557 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group BEFREE <b>Context:</b> Increased vascular cell adhesion molecule-1 (VCAM-1) has been reported to be a critical link between obesity and atherosclerotic cardiovascular diseases while dipeptidyl peptidase-4 (DPP-4) has been implicated in the development of disrupted glucose regulation and inflammation. 31387411 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group BEFREE To better understand the early phases of vascular deterioration in a young, healthy population, we investigated, cross-sectionally, whether biomarkers of endothelial function (intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and von Willebrand factor antigen (vWF<sub>ag</sub>)) are associated with IGF-1 in a healthy study population forming part of the larger African Prospective study on the Early Detection and Identification of Cardiovascular diseases and Hypertension (African-PREDICT). 29936324 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 GeneticVariation group BEFREE Expression of mediators of cholesterol transport, namely the lectin-like oxidized low-density lipoprotein receptor (LOX)-1 and ATP-binding cassette transporter (ABCA)-1, inflammatory markers tumor necrosis factor (TNF)-α and interleukin (IL)-1β/IL-6, nuclear-factor kappa-light-chain-enhancer of activated B cells (NF-κB), intracellular/vascular adhesion molecule(s) (VCAM-1, ICAM-1), and miRNAs (miR-221/-21/-1), associated with cardiovascular disease (CVD), were analyzed in cardiac tissue and coronary vasculature. 30081225 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group BEFREE Dysregulation of vascular cell adhesion molecule-1 may be an early event in the natural history of cardiovascular disease in women with recent glucose intolerance in pregnancy. 29871496 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group BEFREE Adding VCAM-1 to a CVD risk prediction model containing conventional risk factors did not improve the C-index or net reclassification. 28202840 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 GeneticVariation group BEFREE Of the 170 SNPs tested, multiplicative interactions between well-water arsenic and two SNPs, rs281432 in ICAM1 (padj = 0.0002) and rs3176867 in VCAM1 (padj = 0.035), were significant for CVD after adjustment for multiple testing. 25575156 2015
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group CTD_human Of the 170 SNPs tested, multiplicative interactions between well-water arsenic and two SNPs, rs281432 in ICAM1 (padj = 0.0002) and rs3176867 in VCAM1 (padj = 0.035), were significant for CVD after adjustment for multiple testing. 25575156 2015
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 GeneticVariation group BEFREE No effect of VCAM-1 polymorphism on stroke or CVD risks was detected. 25175566 2015
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group BEFREE A direct correlation was found between subjects categorized at higher risk for cardiovascular disease based upon serum triglycerides and postprandial production of TGRL particles that increased VCAM-1-dependent monocyte adhesion to inflamed endothelium. 24205197 2013
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group BEFREE SNPs in miRNA-processing genes may modify associations between ambient pollution and sICAM-1 and sVCAM-1, which are correlates of atherosclerosis and cardiovascular disease. 21600003 2011
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression group BEFREE Adhesion molecules L-, E- and P-Selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) are some of the major regulators of the immune processes and altered levels of these proteins have been found in pathological states including cardiovascular diseases, arthritis and liver cancer. 20193033 2010
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group LHGDN Positive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia. 17714716 2008
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression group LHGDN Endothelial function and markers of endothelial activation in relation to cardiovascular disease in systemic lupus erythematosus. 18666029 2008
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group BEFREE Isoflavones have beneficial effects on CRP concentrations, but not on other inflammatory biomarkers of cardiovascular disease risk in postmenopausal women, and may improve VCAM-1 in an ERbeta gene polymorphic subgroup. 16332659 2005
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker group CTD_human Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. 16332659 2005