|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate the potential of vascular cell adhesion molecule 1 (VCAM-1)-targeted MRI for early detection of brain micrometastases in mouse models across multiple primary tumor types.<b>Experimental Design:</b> Xenograft models of brain micrometastasis for human breast carcinoma (MDA231Br-GFP), lung adenocarcinoma (SEBTA-001), and melanoma (H1_DL2) were established via intracardiac injection in mice.
|
30389659 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As VCAM-1 is a major receptor for α4 integrin and plays a key role in leukocyte recruitment, we reasoned that inhibition of FAK activity may reduce VCAM-1 expression within LNs and thus reduce metastasis of α4 integrin-expressing melanoma to LNs.
|
30660359 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate-severe OSA: OR 2.35, p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis <i>via</i> integrin-based adhesion.
|
29519923 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The regulation of melanoma cell plasticity by VCAM-1 highlights the complex regulation of tumor-matrix interactions.<b>Implications:</b> Nanotechnology has revealed a novel dichotomic function of the VCAM-1/VLA-4 interaction on melanoma cell plasticity, as nanoscale tuning of this interaction reciprocally determines adhesion and spreading in a ligand density-dependent manner.<i></i>.
|
29222169 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous studies suggested that a spatial organization of α4 integrin, one of the two subunits of VLA-4, on the melanoma cell surface contributed to the changes in avidity for VCAM-1 upon UVB-irradiation.
|
21129359 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that melanoma-induced VE-cadherin junction disassembly and upregulation of p38 MAP kinase in endothelial cells is regulated by both soluble factors from melanomas, particularly interleukin (IL)-8, IL-6, and IL-1beta, and through vascular cell adhesion molecule-1.
|
20181932 |
2010 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In this study we show that human melanoma cells with different metastatic potency, which do not express beta2 or beta3 integrins, express the VCAM-1 receptor alpha4beta1.
|
17352405 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treating the EC with monoclonal antibodies to VCAM-1 and E-selectin abolished the colony-6-CM-induced increase in adhesion respectively to A375P melanoma and HT-29 colon-carcinoma cells.In vivo, i.v. injection of colony-6 cells in nude mice increased the expression of VCAM-1 on lung microvascular EC.
|
8824559 |
1996 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When melanoma and endothelioma cells were cultured on either side of a Nucleopore membrane, the expression of VCAM-1 on the endothelioma cells was inhibited and VCAM-1 gene transcription was suppressed.
|
7530765 |
1995 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A form consisting of the first two domains of VCAM-1 is shown to promote very-late antigen-4-dependent spreading of a melanoma cell line comparable to that found for the equivalent region in the full seven-domain form.
|
7528140 |
1994 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although, unlike ICAM-1, VCAM-1 is not correlated with tumor progression, its expression in a fraction of primary melanomas indicates that it may play a role in regulating host immune response and homotypic interactions in some malignant melanomas.
|
1281617 |
1992 |