Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion
0.040 AlteredExpression disease BEFREE Endothelial up-regulation of VCAM-1 at susceptible sites in arteries modulates the recruitment efficiency of inflammatory monocytes that initiates atherosclerotic lesion formation. 31499005 2019
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion
0.040 AlteredExpression disease BEFREE Compared with ApoE<sup>-/-</sup> mice, treatment by juglone resulted not only in markedly attenuated macrophage infiltration and atherosclerotic lesion area in a lipid-independent manner, but also in decreased expression of Pin1, vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and NF-κB activity in aorta. 28300760 2017
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion
0.040 AlteredExpression disease BEFREE Importantly, SIRT6(+/-); ApoE(-/-) mice after HFD feeding exhibited exacerbated atherosclerotic lesion development, concurrent with increased expression of the proinflammatory cytokine VCAM-1. 27249230 2016
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion
0.040 AlteredExpression disease BEFREE Administration with simvastatin in ApoE(-/-) mice markedly attenuated the vascular inflammation and atherosclerotic lesion area, and decreased the aortic expression of HMGB1, RAGE, VCAM-1, and MCP-1. 23564080 2013