Papillary Renal Cell Carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In the Oncomine database, FBXO11 mRNA levels were lower in normal tissues than in cancer tissues, including clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC), hereditary ccRCC, non-hereditary ccRCC, VHL mutant ccRCC and VHL wild-type ccRCC.
|
31159774 |
2019 |
Papillary Renal Cell Carcinoma
|
0.370 |
PosttranslationalModification
|
disease |
BEFREE |
The molecular mechanisms involved in pRCC development and drug resistance are more diverse than in clear-cell RCC, in which inactivation of VHL occurs in the majority of tumours.
|
31602010 |
2019 |
Papillary Renal Cell Carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
While the inactivation of VHL gene can be found in the majority of clear cell carcinomas, different molecular mechanisms are involved into pRCC biology.
|
26052049 |
2015 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2α.
|
24755467 |
2014 |
Papillary Renal Cell Carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
It exhibits a different molecular signature than clear-cell carcinoma and is typically not associated with mutations in the VHL (von Hippel-Lindau) tumor suppressor gene. pRCC is less responsive to modern drugs introduced in the management of kidney cancer in the past decade.
|
24629521 |
2014 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Integrated molecular analysis of clear-cell renal cell carcinoma.
|
23797736 |
2013 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
|
22138691 |
2011 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells.
|
21097529 |
2011 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Bilateral renal-cell carcinoma associated with an acquired VHL mutation and long-term trichloroethylene exposure.
|
19473641 |
2009 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
VHL status was assessed in 20 cases of clear cell renal cell carcinoma and 9 cases of papillary renal cell carcinoma by DNA sequencing and by immunohistochemical staining for the hypoxia-inducible factor-alpha target gene products CA9 and GLUT-1.
|
18660794 |
2009 |
Papillary Renal Cell Carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis revealed deletions at 3p25-26 in one translocation carcinoma, one chromophobe renal cell carcinoma, and one papillary renal cell carcinoma.There were no VHL mutations.
|
15316311 |
2004 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
VHL mutations in renal cell cancer: does occupational exposure to trichloroethylene make a difference?
|
15177666 |
2004 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
|
11171960 |
2001 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma.
|
10340905 |
1999 |
Papillary Renal Cell Carcinoma
|
0.370 |
Biomarker
|
disease |
CTD_human |
Renal cell carcinomas in trichloroethene (TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau (VHL) tumour suppressor gene.
|
9137812 |
1997 |
Papillary Renal Cell Carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that mutation of the VHL gene is associated exclusively with the development of non-papillary renal cell carcinoma.
|
8758207 |
1996 |