EZR, ezrin, 7430

N. diseases: 255; N. variants: 4
Disease: Shigella Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013371
Disease: Shigella Infections
Shigella Infections 		0.020 AlteredExpression group BEFREE The recruitment pattern resembled that of rhoC or ezrin, but not rhoA, rac or CDC42, while in vitro GAP activity of myr5 was similar for rhoA, B or C. Analysis of myr5 mutants suggested that GTPase- or ATP-binding activites are not required for Shigella-induced recruitment of this atypical myosin to the bacterial entry site. 11207612 2000
CUI: C0013371
Disease: Shigella Infections
Shigella Infections 		0.020 GeneticVariation group BEFREE In addition, Shigella entry is significantly reduced in cells transfected with a dominant negative allele of ezrin with entry foci showing much shorter cellular protrusions. 10362536 1999