Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of MLK4 inhibited HCC cell proliferation and metastasis, which was partly through reducing matrix metalloproteinase (MMP)-13, MMP2, enhancer of zeste homolog 2 (EZH2) and Vimentin expressions.
|
31071576 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The reduced expression of E-cadherin and enhanced expression of Vimentin and transforming growth factor-beta 1 (TGF-β1) were found in HCC tissue compared with normal liver tissue.
|
30643426 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of ZEB1 and VIM were higher in tumor tissues compared with those in adjacent normal tissues, and they were significantly associated with a poor prognosis in patients with HCC, whereas ZEB1 silencing led to the attenuation of HCC cell proliferation, invasion and migration.
|
30664206 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusions, aberrant methylation of SOX1 and VIM promoters may be potential biomarkers for noninvasive detection of HCC and HCC metastasis.
|
28592127 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, in human HCC tissue samples, Cx32 was positively correlated with the expression of the EMT marker E-cadherin and negatively correlated with the expression of Vimentin.
|
31213923 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, TGM3 knockdown cells had increased E-cadherin levels and decreased vimentin levels, suggesting that TGM3 contributes to epithelial-mesenchymal transition (EMT) in HCC.
|
31822388 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of UPF1 expression on EMT process by targeting E‑cadherin, N‑cadherin, Vimentin and Twist in a hepatocellular carcinoma cell line.
|
30628676 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The silencing of KLF5 in HCC cell lines downregulated the expression of N-cadherin, Vimentin and Snail and increased the expression of the epithelial marker E-cadherin.
|
30473218 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curves for differentiating HCCfrom liver cirrhosis revealed a higher area under the curve(AUC).for vimentin than for AFP, lamin B1, and anti-Ku86 for the diagnosis of HCC (P<0.001).
|
30897324 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data in the present study demonstrated that HDAC1 is overexpressed in HCC and that HDAC1 may upregulate vimentin expression through the NF-κB signaling pathway, thus demonstrating a causal link between HDAC1 and vimentin in HCC, and may provide valuable information in understanding the pathogenesis of HCC.
|
31289505 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ZnAs@SiO<sub>2</sub> NPs also inhibited tumor spheroid formation <i>in vitro</i> and tumor initiation <i>in vivo</i> and induced significant changes in the expression of stemness markers (CD133, Sox-2, and Oct-4) and EMT markers (E-cadherin, Vimentin, and Slug) both <i>in vitro</i> and <i>in vivo.</i> These effects of ZnAs@SiO<sub>2</sub> that correlated with prognosis of HCC were mediated by the SHP-1/JAK2/STAT3 signaling.
|
31285768 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, SIRT6 promoted N-cadherin and Vimentin expression via deacetylating FOXO3a in HCC.
|
31551254 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We documented that miR-HCC2 facilitated the growth, migration and invasion of HCC cells by accelerating cell cycle progression, incressing the expression of epithelial-to-mesenchymal transition (EMT)-associated marker vimentin but decreasing the expression of E-cadherin.
|
31293644 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determined KIAA1199 expression and investigate its correlation with the clinicopathologic data and prognosis of hepatocellular carcinoma (HCC), as well as markers of epithelial-mesenchymal transition (EMT); N-cadherin, E-cadherin and vimentin.
|
30538502 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings indicated that downregulated SIRT5-mediated vimentin acetylation may be involved in the EMT in HCC.
|
30662803 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of JAK2, STAT3 and vimentin were higher in HCC tissues, while the expression of E-cadherin was lower in HCC tissues compared with para-cancerous tissues.
|
30453302 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrated that the levels of MALAT1 and Vimentin were upregulated in HCC tissues and that miR-30a-5p was a direct target of MALAT1.
|
30278452 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our present study found that radiation can promote the migration and invasion of hepatocellular carcinoma (HCC) cells via induction of epithelial mesenchymal transition (EMT), which was evidenced by the results that radiation induced up regulation of vimentin while down regulation of E-Cadherin.
|
29684855 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Compared with that in normal tissue, the expression level of vimentin in HCC tissue was increased, whereas that of E-cadherin was decreased.
|
30233697 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, miR-138 was found to regulate HCC cell viability and migration, and the levels of vimentin and CCND3 protein expression were found to be inversely correlated with those of miR-138 expression.
|
29916745 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ability of HCC CTCs and vimentin (VIM)-positive CTCs (a subpopulation expressing an epithelial-to-mesenchymal phenotype) to accurately discriminate tumor stage, recurrence, progression, and overall survival (OS) was evaluated in a prospective study of 80 patients.
|
29624843 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
They also provide potential therapeutic targets for HCC treatment and provide new insight for circular RNA (circRNA)-based diagnostic and therapeutic strategies.<b>Significance:</b> A circRNA-based mechanism drives Twist1-mediated regulation of vimentin during EMT and provides potential therapeutic targets for treatment of HCC.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/15/4150/F1.large.jpg <i></i>.
|
29844124 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Collectively, the hydroxylase activity of ASPH affected HCC metastasis through interacting with vimentin and regulating EMT.
|
29764768 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that CD13 enrichment was correlated with early recurrences, and poor prognosis in patients with HCC and that vimentin was associated with early recurrences.
|
29145632 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, the decreased miR-26a-5p level observed in HCC was associated with reduced E-cadherin expression and upregulation of vimentin, which affects the molecular mechanism of EMT.
|
27864783 |
2017 |