Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia.
|
29699729 |
2018 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, suppression of vasoactive intestinal peptide (VIP) expression alone induced neuroblastoma cell differentiation, and VIP was up-regulated by TG2-L, but not TG2-S. Taken together, our data indicate that TG2-L and TG2-S exert opposite effects on cell differentiation due to differences in GTP binding and modulation of VIP gene transcription.
|
20007697 |
2010 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The resemblance of the signaling pathways involving concomitant activities of PKC, ERK1/2 and PKA in PACAP regulation of the FOS and VIP gene expressions suggest for the first time a role of FOS in PACAP-induced VIP gene expression in human NB-1 neuroblastoma cells.
|
19712974 |
2009 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, SNAP-25 is up-regulated and implicated in neuritogenesis in human neuroblastoma SH-SY5Y cells treated with the neuropeptide VIP.
|
18617262 |
2009 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine whether VIP could modulate MYCN expression, we carried out real-time quantitative RT-PCR and Western immunoblot analyses in human neuroblastoma SH-SY5Y and IMR-32 cells.
|
18949372 |
2008 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Endogenous VIP expression is high in SH-EP neuroblastoma cells, low but inducible in SH-SY5Y cells, and absent in HeLa cells.
|
15009665 |
2004 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data support the hypothesis that VIP modulation of neural crest differentiation is mediated via VPAC1 and that high expression of VPAC1 induces differentiation in and decreases tumorigenicity of neuroblastoma cells.
|
12409228 |
2002 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have shown before that VIP antagonists are potent inhibitors of neoplastic growth of neuroblastoma, lung and breast cancer cells in vitro.
|
12409224 |
2002 |
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SK-N-SH human neuroblastoma subclones differ widely in basal and second messenger induction of the gene encoding the neuropeptide vasoactive intestinal peptide (VIP).
|
11374892 |
2001 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We therefore investigated whether PACAP affected the VIP gene expression and elucidated the molecular mechanisms using the human neuroblastoma cell line NB-1.
|
10925144 |
2000 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To investigate the molecular mechanisms by which activin regulates neuronal gene expression, we have examined activin's regulation of VIP gene expression in NBFL neuroblastoma cells.
|
10707960 |
2000 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The studies indicate that several components of the VIP/PACAP autocrine system are regulated in neuroblastoma cell lines during RA differentiation.
|
9285932 |
1997 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cholinergic regulation of VIP gene expression in human neuroblastoma cells.
|
9439833 |
1997 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, the VIP analog was found to displace VIP from its binding sites on LA-N-2 human neuroblastoma cells (VIP IC50: 5.4 nM; VIP analog IC50: 52.2 nM) and to inhibit the VIP-induced cyclic AMP production of 58 +/- 15% at 1 microM and 95 +/- 2% at 10 microM.
|
7972935 |
1994 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we present data on the effects of retinoic acid (RA), a known modulator of neuronal differentiation, on VIP gene expression in the human neuroblastoma cell line NB-1.
|
7925107 |
1994 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concomitant enhancement of both intracellular and extracellular VIP expression, coupled with the induction of functional specific VIP receptors during VIP-induced differentiation, provides critical evidence for the autocrine regulation of neuroblastoma maturation by this peptide.
|
8387768 |
1993 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We now show that VIP had mitogenic activity in a human neuroblastoma cell line (NMB), as measured by cell number and thymidine incorporation.
|
8252411 |
1993 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RIA of VIP and SRIF levels in primary tumor tissue may offer an independent objective assay of biologic behavior in neuroblastoma biopsy specimens.
|
1381992 |
1992 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These and other data indicate that multiple transcriptional elements control VIP expression in neuroblastoma cells and are candidates as mediators of VIP gene expression in the intact animal.
|
2079711 |
1990 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional vasoactive intestinal polypeptide (VIP) receptors in human neuroblastoma subclones that contain VIP precursor mRNA and release VIP-like substances.
|
2537287 |
1989 |
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Lineage-specific regulation of the vasoactive intestinal peptide gene in neuroblastoma cells is conferred by 5.2 kilobases of 5'-flanking sequence.
|
3200839 |
1988 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Synergistic stimulation of VIP/PHM-27 gene expression by cyclic AMP and phorbol esters in human neuroblastoma cells.
|
2416313 |
1985 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The quantity of VIP/PHM-27 gene in the DNA of neuroblastoma cells was analyzed after hydrolysis with a restriction endonuclease, EcoRI.
|
6086627 |
1984 |