Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor.
|
31753928 |
2019 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated whether VWF-HMWM level at acute phase of TTP could be a predictive factor for morbidity.
|
31330376 |
2019 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Comparison of ADAMTS13 and Von Willebrand factor levels and activities, and plasminogen levels, in plasma products currently available for the treatment of thrombotic thrombocytopenic purpura in South Africa.
|
30551950 |
2019 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Link between von Willebrand factor multimers, relapses and coronary microcirculation in patients with thrombotic thrombocytopenic purpura in remission.
|
30471507 |
2019 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
TTP is a deficiency of a disintegrin and metalloprotease with thrombospondin type 1 motif 13 resulting in von Willebrand factor aggregates.
|
30776151 |
2019 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present review, we focus on aptamers as potential therapeutics for hematological diseases, including anemia of chronic inflammation (ACI) and anemia of chronic disease (ACD), hemophilia, thrombotic thrombocytopenic purpura (TTP) or VWD type-2B, and sickle cell disease (SCD), in particular, those that have entered into clinical trials.
|
28969551 |
2019 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Force-regulated cleavage of A2 domain of von Willebrand factor (vWF) by ADAMTS13 is a key event in preventing thrombotic thrombocytopenic purpura (TTP).
|
29636514 |
2018 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
As the anchored VWF chains grow, they provide a greater surface area to bind circulating platelets (PLTs), generating unique thrombi that characterize TTP.
|
30208220 |
2018 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, (4) studies of patients with primary disorders of excess or deficiency of function in the vWF axis (e.g. thrombotic thrombocytopenic purpura and von Willebrand disease, respectively) which demonstrate the crucial role of vWF in atherothrombosis.
|
29847840 |
2018 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent insights into TTP pathogenesis have led to the development of novel therapies targeting pathogenic anti-ADAMTS13 antibody production, von Willebrand factor (VWF)-platelet interactions, and ADAMTS13 replacement.
|
30504355 |
2018 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thrombotic thrombocytopenic purpura (TTP) is caused by inactivation of a von Willebrand factor (VWF)-cleaving enzyme, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), which leads to platelet-rich thrombi comprising unusually large VWF multimers.
|
29228282 |
2018 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present case report described a patient with thrombotic thrombocytopenic purpura (TTP), who presented to the China-Japan Union Hospital of Jilin University (Changchun, China), and the changes in plasma von Willebrand factor (vWF) and vWF cleaving protease (vWF-cp) observed during treatment.
|
29250148 |
2018 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>N</i>-acetylcysteine (NAC), an FDA-approved anti-mucolytic agent, is a possible new treatment strategy for TTP, as it was demonstrated to reduce disulfide bonds in VWF, thereby decreasing VWF multimers size and hence their prothrombotic potential.
|
28011677 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAMTS13 and von Willebrand factor (VWF) are closely related to the onset of TTP.
|
26759371 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
von Willebrand factor and its cleaving protease ADAMTS13 balance in coronary artery vessels: Lessons learned from thrombotic thrombocytopenic purpura. A narrative review.
|
28521259 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thrombotic thrombocytopenic purpura (TTP) is an acute life-threatening microangiopathy with a tendency of relapse characterized by consumptive thrombocytopenia, microangiopathic hemolytic anemia, and spontaneous von Willebrand factor-induced platelet clumping leading to microthrombi.
|
28337761 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thrombotic thrombocytopenic purpura (TTP) is a rare but serious disease caused by autoantibody-mediated deficiency in von Willebrand factor (VWF) cleaving protease, ADAMTS-13.
|
27246502 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Objectives Investigate if endogenous plasmin-mediated proteolysis of VWF can influence acute TTP episodes.
|
28981198 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thrombotic thrombocytopenic purpura (TTP), a potentially fatal clinical syndrome, is primarily caused by autoantibodies against the von Willebrand factor (VWF)-cleaving metalloprotease ADAMTS-13.
|
28662310 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ultra-large vWF strings remain uncleaved after endothelial cell secretion and anchorage, bind to platelets and form microthrombi, leading to the clinical manifestations of TTP.
|
28382967 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are several distinct pathophysiologies leading to microangiopathic hemolysis, ranging from decreased degradation of von Willebrand factor as seen in thrombotic thrombocytopenic purpura (TTP) to endothelial damage facilitated by Escherichia coli shiga toxin or complement dysregulation, seen in shiga toxin-related hemolytic-uremic syndrome (Stx-HUS) and complement-mediated TMA (also called atypical hemolytic-uremic syndrome), respectively.
|
28447417 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inherited or acquired ADAMTS13 deficiency allows the unrestrained growth of microthrombi that are composed of von Willebrand factor and platelets, which account for the thrombocytopenia, hemolytic anemia, schistocytes, and tissue injury that characterize TTP.
|
28768626 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Future studies may be warranted to determine whether higher baseline VWF can be a trigger for TTP, or can confer protection by competing with a newly secreted ULVWF for platelet binding.
|
28369949 |
2017 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Despite a clinical diagnosis of TTP, the patient had normal ADAMTS-13 levels and increased VWF antigen levels with ultra-large von Willebrand factor multimers.
|
26613809 |
2016 |
Purpura, Thrombotic Thrombocytopenic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Acquired thrombotic thrombocytopenic purpura (TTP) is a potentially fatal disease in which ultralarge von Willebrand factor (UL-VWF) multimers accumulate as a result of autoantibody inhibition of the VWF protease, ADAMTS13.
|
27040023 |
2016 |