WFS1, wolframin ER transmembrane glycoprotein, 7466

N. diseases: 185; N. variants: 80
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 GeneticVariation disease BEFREE Given the complexity of WS, this case suggests that the possible association between WS and BD should not only be merely limited to a possible statistical association with WFS1 polymorphism but also to developmental, cognitive, and endocrine risk factors for BD. 27045389 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 Biomarker disease PSYGENET The gene expression profile in the hypothalami of the Wfs1 mutant mice was significantly similar to the profiles of following biological functions: psychological disorders, bipolar disorder, mood disorder. 22028430 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 AlteredExpression disease BEFREE These results suggest that the therapeutic effects of valproate in bipolar disorder may be mediated by WFS1 expression and its dissociation from GRP94. 19125190 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 Biomarker disease PSYGENET These results suggest that the therapeutic effects of valproate in bipolar disorder may be mediated by WFS1 expression and its dissociation from GRP94. 19125190 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 Biomarker disease PSYGENET Because WfS1, the causative gene of Wolfram disease, is located at 4p16, a linkage locus for bipolar disorder, mutations of WfS1 were suggested to be involved in the pathophysiology of bipolar disorder. 18343518 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 Biomarker disease PSYGENET Various other protein products of genes associated with bipolar disorder either bind to or are affected by phosphatidyl-inositol phosphate products of this pathway (ADBRK2, HIP1R, KCNQ2, RGS4, WFS1), are associated with its constituent elements (BCR, DUSP6, FAT, GNAZ) or are downstream targets of this signalling cascade (DPYSL2, DRD3, GAD1, G6PD, GCH1, KCNQ2, NOS3, SLC6A3, SLC6A4, SST, TH, TIMELESS). 17239488 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 Biomarker disease PSYGENET Five SNPs in the WFS1 gene were associated with major depressive disorder, and three SNPs with bipolar disorder. 15473915 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 GeneticVariation disease BEFREE Five SNPs in the WFS1 gene were associated with major depressive disorder, and three SNPs with bipolar disorder. 15473915 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 GeneticVariation disease BEFREE Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder. 15234338 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 Biomarker disease BEFREE These results did not support the pathophysiological significance of WFS1 in bipolar disorder. 12565131 2003
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.360 GeneticVariation disease BEFREE WFS1 gene mutation search in depressive patients: detection of five missense polymorphisms but no association with depression or bipolar affective disorder. 10760554 2000