WNT9A, Wnt family member 9A, 7483

N. diseases: 17; N. variants: 2
Disease: Kidney Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.010 AlteredExpression group BEFREE Compared with tubular cells of normal subjects, tubular cells of humans with a variety of nephropathies and those of several mouse models of CKD expressed high levels of Wnt9a that colocalized with the senescence-related protein p16<sup>INK4A</sup> Wnt9a expression level correlated with the extent of renal fibrosis, decline of eGFR, and expression of p16<sup>INK4A</sup> Furthermore, ectopic expression of Wnt9a after ischemia-reperfusion injury (IRI) induced activation of <i>β</i>-catenin and exacerbated renal fibrosis. 29440280 2018