WRN, WRN RecQ like helicase, 7486

N. diseases: 172; N. variants: 89
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 AlteredExpression disease BEFREE WRN mRNA and WRN protein expression levels were low in colorectal cancer cell lines and in primary colorectal cancer and were largely independent of WRN methylation status. 27121793 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 GeneticVariation disease BEFREE WRN Cys1367Arg variants carriers showed an increased susceptibility for CRC. 25355595 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 GeneticVariation disease BEFREE This is the first study to analyze the associations between polymorphisms in WRN, BLM and RMI1 and CRC risk. 19945966 2010
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 PosttranslationalModification disease BEFREE Utilizing 903 population-based colorectal cancers and real-time PCR (MethyLight), we quantified DNA methylation in WRN and eight other promoters (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) known to be specific for CIMP. 18084250 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 Biomarker disease BEFREE Utilizing real-time polymerase chain reaction (PCR; MethyLight technology), we quantified DNA methylation in 13 CpG island loci (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, SOCS1, MINT1, MINT31, IGFBP3, MGMT, and WRN) in 30 metastatic microsatellite stable colorectal carcinomas in phase I/II clinical trials of combination chemotherapy (5-fluorouracil, irinotecan, leucovorin, and gefitinib). 17372756 2007
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 GeneticVariation disease UNIPROT