Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
ZAP-70 did not correlate with any underlying cytogenetic abnormality.
|
27221715 |
2018 |
Congenital chromosomal disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Correlation analysis was performed to assess associations between CacyBP/SIP expression and clinical stage, chromosome abnormalities and zeta-chain-associated protein kinase 70 (ZAP-70) expression.
|
26603518 |
2016 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Prognostic factors such as chromosome abnormalities (trisomy 12, 11q deletions and 17p deletions), β2 microglobulin, thymidine kinase, CD38 and ZAP-70 expression, IGHV mutation status, and mutations in genes such as NOTCH1, MYD88, SF3B1, and ATM are also predictors of prognosis.
|
27742074 |
2016 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The EBV-DNA copy number/μg DNA was significantly higher in patients who required early implementation of treatment, presented with lymphocyte count doubling time <12 months, displayed CD38-positive or ZAP-70-positive phenotype, and with the del(11q22.3) cytogenetic abnormality.
|
26460692 |
2015 |
Congenital chromosomal disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the overall patient population, prognostic parameters such as IGHV gene mutational status (P < .0001), CD38 expression (P < .0001), 70-kDa zeta-associated protein (ZAP-70) expression (P < .0001), and cytogenetic abnormalities (P = .01) predicted for TTFT on univariate analysis.
|
25445470 |
2015 |
Congenital chromosomal disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No genotype or allele was significantly associated with important prognostic factors in CLL including clinical stage, IgVH mutational status, ZAP-70 expression and FISH cytogenetic abnormalities.
|
25488616 |
2015 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of ZAP-70 mRNA was significantly associated with Binet stage (P < 0.001), lactate dehydrogenase (P = 0.003), ZAP-70 protein (P = 0.018), IGHV mutational status (P = 0.038), and cytogenetic abnormality of del(17p13) or del(11q22.3) (P = 0.037) in CLL patients.
|
22362302 |
2012 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
On pooled multivariable analysis of patients in both cohorts adjusting for age, sex, Rai stage, CD38 status, ZAP-70 status, immunoglobulin heavy chain variable (IGHV) gene mutation status, CD49d status, and cytogenetic abnormalities assessed by interphase fluorescent in situ hybridization testing, 25(OH)D insufficiency remained an independent predictor of TTT (HR = 1.47; P = .008), although the association with OS was not significant (HR = 1.47; P = .07).
|
21048153 |
2011 |
Congenital chromosomal disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities.
|
20880586 |
2011 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
According to the correlation analysis, advanced Binet stage (r=0.314, P<0.001), direct antiglobulin test (DAT)-positive (r=0.366, P<0.001), high level of serum β2-microglobulin (β2-MG) (r=0.296, P=0.001) and thymidine kinase (TK) 1 (r=0.227, P=0.037), unmutated immunoglobulin heavy chain variable gene (IGHV) status (r=0.284, P=0.002), ZAP-70-positive (r=0.305, P=0.001), CD38-positive (r=0.284, P=0.002), and cytogenetic abnormalities of del(17p13) or del(11q22.3) (r=0.208, P=0.032) emerged as factors significantly related to the occurrence of Ig paraproteinemia.
|
21208658 |
2011 |
Congenital chromosomal disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our aim was to evaluate the optimal cut-off for IgVh mutational status, ZAP-70 expression and cytogenetic abnormalities in association with disease progression defined as the need for treatment within 3~years from diagnosis in 170 patients with B-CLL.
|
20164537 |
2010 |
Congenital chromosomal disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Clinical features and molecular/biologic factors such as ZAP-70, immunoglobulin heavy chain (IGHV) gene mutation status, and cytogenetic abnormalities on fluorescent in situ hybridization (FISH) have been found to be robust predictors of treatment-free survival and overall survival among newly diagnosed patients.
|
20008228 |
2009 |
Congenital chromosomal disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ZAP-70 expression was not related to the other poor prognosis cytogenetic abnormality del(11q22.3) nor to trisomy 12.
|
18223290 |
2008 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Studies to determine how to integrate variables reflecting increased angiogenesis with other prognostic markers such as CD38, ZAP-70, IgV(H) status and cytogenetic abnormalities are needed to optimize risk stratification for individual patients.
|
17485110 |
2007 |
Congenital chromosomal disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Elevated TK levels were also found in patients with CD38 and Zap-70 positivity (P = 0.004, P < 0.001, respectively), short lymphocyte doubling time (LDT) (P = 0.044) and poor or intermediate prognosis chromosomal aberrations (P < 0.001).
|
16856923 |
2006 |
Congenital chromosomal disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The recognition of the prognostic role of IgVH hypermutation status and related phenotypic changes (CD38, ZAP-70 expression) as well as of chromosome abnormalities defined by cytogenetic analysis enabled a refined classification of the disease.
|
16388316 |
2005 |
Congenital chromosomal disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Recently, several important observations related to the biologic significance of V(H) mutational status and associated ZAP-70 overexpression, disrupted p53 function, and chromosomal aberrations have led to the ability to identify patients at high risk for early disease progression and inferior survival.
|
15561682 |
2004 |