|
Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
In mice, TTP deficiency results in a systemic autoimmune inflammatory syndrome with severe arthritis.
|
16546352 |
2006 |
|
Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
When the gene encoding TTP is disrupted in mice, the animals develop a severe syndrome of arthritis, autoimmunity, cachexia, dermatitis, and myeloid hyperplasia.
|
27503556 |
2016 |
|
Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
Along with decreased proinflammatory cytokines in their paw joints, there were significant functional and histologic improvements in the inflammatory arthritis of TTP(-/-) mice when CCL3 was absent, although cachexia, reflecting systemic inflammation, was notably unaffected.
|
21784977 |
2011 |
|
Arthritis
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis.
|
15535838 |
2004 |
|
Arthritis
|
0.360 |
Biomarker
|
disease |
CTD_human |
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.
|
15944294 |
2005 |
|
Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
In summary, these findings expand current views on the initiation of psoriasis and related arthritis by revealing the keratinocyte-intrinsic role of TTP.
|
28570274 |
2017 |
|
Arthritis
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Substitution of TTP phosphorylation sites conferred dramatic protection against inflammatory arthritis in mice.
|
27597652 |
2017 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to elucidate the role of TTP in hepatocarcinogenesis and HCC progression.
|
31717307 |
2019 |
|
Liver carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, MK2 was activated in primary HCC that express TTP at high level.
|
27619201 |
2016 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Quantitative analysis showed that IMAX, RT, TTP, and mTT of HCC were statistically different with that of reference liver parenchyma (all p ＜ .001).
|
30300039 |
2019 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Abrogation of the post-transcriptional regulation of c-Myc via methylation of a specific single CpG site in the TTP promoter presents a novel mechanism for the gain of selective resistance to the antiproliferative signaling of TGF-beta1 in HCC.
|
20038433 |
2010 |
|
Dermatitis
|
0.310 |
Biomarker
|
disease |
BEFREE |
Mice deficient of TTP (TTP(-/-)) develop a systemic autoimmune inflammatory syndrome characterized by cachexia, conjunctivitis, and dermatitis.
|
23997224 |
2013 |
|
Dermatitis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.
|
15944294 |
2005 |
|
Polyarthritis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.
|
15944294 |
2005 |
|
Polyarthritis
|
0.310 |
Biomarker
|
disease |
BEFREE |
This activity was discovered after TTP-deficient mice were created and found to have a systemic inflammatory syndrome with severe polyarticular arthritis and autoimmunity, as well as medullary and extramedullary myeloid hyperplasia.
|
15535838 |
2004 |
|
Alopecia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.
|
15944294 |
2005 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
miR-346 controls release of TNF-α protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization.
|
21611196 |
2011 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
TTP expression was significantly higher in RA than non-inflamed synovium, detected in macrophages, vascular endothelial cells and some fibroblasts and co-localised with MAPK p38 activation.
|
27597652 |
2017 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We measured the gene expression of ARBPs, including tristetraprolin, T-cell intracellular antigen (TIA)-1 and Hu antigen R (HuR), in synovial tissues from RA and osteoarthritis patients. cDNA was constructed from synovial tissues obtained from 21 patients with RA, and those from 12 patients with osteoarthritis.
|
16820934 |
2006 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis.
|
16820934 |
2006 |
|
Rheumatoid Arthritis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We studied the difference in promoter activity between the two alleles by luciferase assay and found that the promoter activity of TTP promoter region with allele A was around two-fold higher than that with allele G. We conclude that this SNP in the promoter region of the TTP gene mildly affects promoter activity, and thus, may influence the disease activity of inflammatory disorders including RA.
|
18536977 |
2008 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results suggested that CRT could promote ICAM-1 expression in endothelial cells through PI3K/Akt/eNOS/p38 MAPK signaling mediated TTP accumulation, probably in an inactive form, which may provide a possible proinflammatory mechanism of CRT in RA.
|
30639474 |
2019 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis.
|
15170914 |
2004 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The data presented here suggest a tentative association between ZFP36 and RA.
|
16546352 |
2006 |