ZFY, zinc finger protein Y-linked, 7544

N. diseases: 20; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041408
Disease: Turner Syndrome
Turner Syndrome 		0.040 GeneticVariation disease BEFREE The PCR analysis with the Y-specific sequences ZFY and DYZ3 were identified in two different patients (4.8%), both with karyotype 45,X. 19172542 2008
CUI: C0041408
Disease: Turner Syndrome
Turner Syndrome 		0.040 Biomarker disease BEFREE To identify patients at risk of developing gonadoblastoma, a PCR based assay with SRY, ZFY and DYZ3 specific primers was carried out to detect different Y-sequences in the DNA of peripheral lymphocytes from patients with Turner's syndrome. 10341852 1999
CUI: C0041408
Disease: Turner Syndrome
Turner Syndrome 		0.040 Biomarker disease BEFREE The zinc-finger proteins ZFX and ZFY, encoded by genes on the mammalian X and Y chromosomes, have been speculated to function in sex differentiation, spermatogenesis, and Turner syndrome. 9187153 1997
CUI: C0041408
Disease: Turner Syndrome
Turner Syndrome 		0.040 Biomarker disease BEFREE The X,t(Y;22) female lacks the ZFY gene but does not exhibit the complex phenotype known as Turner's syndrome, arguing against the hypothesis that ZFY is the Turner's syndrome gene on the Y chromosome. 1973823 1990
CUI: C0432475
Disease: XX males
XX males 		0.020 GeneticVariation disease BEFREE These observations on Y - ve XX males and an additional exceptional Y + patients suggest that the ZFY locus is not essential for male differentiation and is not the primary testis determining factor. 2298458 1990
CUI: C0432475
Disease: XX males
XX males 		0.020 Biomarker disease BEFREE An extended long-range restriction map of the human sex-determining region on Yp, including ZFY, finds marked homology on Xp and no detectable Y sequences in an XX male. 2705458 1989
CUI: C0013336
Disease: Dwarfism
Dwarfism 		0.010 Biomarker disease BEFREE A rare case of a male with 45, XO, SRY+, ZFY+ with short stature and mild Turner stigmata. 22832081 2012
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.010 GeneticVariation disease BEFREE A chromosome-dosage comparison of the hypermethylated HLCS and ZFY loci could distinguish samples of T21 and euploid placental DNA. 19850629 2010
CUI: C0152096
Disease: Complete trisomy 18 syndrome
Complete trisomy 18 syndrome 		0.010 Biomarker disease BEFREE The ratios of methylated VAPA-APCDD1(chr18) to ZFY(chrY) were higher in maternal plasma samples of 9 male trisomy 18 fetuses than those of 27 male euploid fetuses (Mann-Whitney test, P=0.029). 21152411 2010
CUI: C4317091
Disease: Trisomy 18 Syndrome
Trisomy 18 Syndrome 		0.010 Biomarker disease BEFREE The ratios of methylated VAPA-APCDD1(chr18) to ZFY(chrY) were higher in maternal plasma samples of 9 male trisomy 18 fetuses than those of 27 male euploid fetuses (Mann-Whitney test, P=0.029). 21152411 2010
CUI: C0242526
Disease: Gonadal Dysgenesis, 45,X
Gonadal Dysgenesis, 45,X 		0.010 GeneticVariation disease BEFREE The PCR analysis with the Y-specific sequences ZFY and DYZ3 were identified in two different patients (4.8%), both with karyotype 45,X. 19172542 2008
CUI: C0018055
Disease: Gonadal Dysgenesis, Mixed
Gonadal Dysgenesis, Mixed 		0.010 Biomarker disease BEFREE While mosaicism alone might have accounted for the phenotypic differences, by PCR analysis the Turner syndrome patient was SRY and ZFY negative and the mixed gonadal dysgenesis patient was SRY and ZFY positive. 9783714 1998
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.010 GeneticVariation disease BEFREE Molecular studies of this familial inverted Y chromosome showed no differences in the ZFY and TSPY genes between the father and the patient suggesting that the short arm of our patient's inv(Y) is identical to that of the patient's father. 9128931 1997
CUI: C0266362
Disease: Ambiguous Genitalia
Ambiguous Genitalia 		0.010 Biomarker disease BEFREE We report a Mexican 46,XX male patient without genital ambiguities in whom DNA analysis showed the presence of SRY and the absence of ZFY. 7726236 1995
CUI: C0848558
Disease: Hypospadias
Hypospadias 		0.010 Biomarker disease BEFREE Molecular studies revealed Yp sequences in two individuals (ZFY+ SRY+) with different phenotypes, a third one presented with a smaller segment of Yp (ZFY- SRY+) and complete virilization, while the remaining three were Y-negative and showed hypospadias. 7586641 1995
CUI: C1691215
Disease: Penile hypospadias
Penile hypospadias 		0.010 Biomarker disease BEFREE Molecular studies revealed Yp sequences in two individuals (ZFY+ SRY+) with different phenotypes, a third one presented with a smaller segment of Yp (ZFY- SRY+) and complete virilization, while the remaining three were Y-negative and showed hypospadias. 7586641 1995
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 AlteredExpression group BEFREE We found expression of ZFY transcripts in 3 of 31 prostate adenocarcinomas by using Northern analysis. 7680890 1993
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE Southern analysis revealed that the portion of the Y chromosome which contains the ZFY gene was not lost from the majority of the tumor cells in any of the prostate malignancies examined.(ABSTRACT TRUNCATED AT 250 WORDS) 7680890 1993
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate 		0.010 AlteredExpression disease BEFREE We have analyzed samples of human prostate adenocarcinoma for the expression of ZFY and ZFX transcripts. 7680890 1993
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 AlteredExpression group BEFREE When we used reverse transcriptase PCR (RT-PCR) to analyze these same samples, the number of tumors expressing ZFY and/or ZFX transcripts increased to 20 of 31. 7680890 1993
CUI: C0018054
Disease: Gonadal Dysgenesis, 46,XY
Gonadal Dysgenesis, 46,XY 		0.010 GeneticVariation disease BEFREE Investigation of the ZFY gene in XX true hermaphroditism and Swyer syndrome. 2358305 1990
CUI: C0432470
Disease: 46, XY female
46, XY female 		0.010 Biomarker disease BEFREE The absence of testicular differentiation in the ZFY-positive XY female evidences functionally altered sex determination or, alternatively, defective gonadal receptors. 2358305 1990
CUI: C0432481
Disease: 46, XX true hermaphrodite
46, XX true hermaphrodite 		0.010 Biomarker disease BEFREE A reanalysis of these cases shows them all to lack ZFY, but one 46,XX true hermaphrodite carries sequences next to the Y pseudoautosomal boundary. 2227958 1990
CUI: C2936694
Disease: Swyer Syndrome
Swyer Syndrome 		0.010 GeneticVariation disease BEFREE Investigation of the ZFY gene in XX true hermaphroditism and Swyer syndrome. 2358305 1990