|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this experimental study, human SSCs were isolated and their identities were confirmed by tracking their promyelocytic leukemia zinc finger (PLZF) protein.
|
30123997 |
2019 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, under steady-state conditions, DP T cells expressed eomesodermin (Eomes) and promyelocytic leukemia zinc finger (PLZF) proteins, both of which act as transcription factors in innate/memory-like T cells.
|
30116750 |
2018 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CDC: Centers for Disease Control; DMSO: dimethyl sulfoxide; GHR: growth hormone receptor; hESCs: human embryonic stem cells; PFASs: per- and polyfluoroalkyl substances; PFCs: perfluorinated compounds; PFNA: perfluorononanoic acid; PFOS: perfluorooctanesulfonic acid; PFOA: perfluorooctanoic acid; PLZF: promyelocytic leukemia zinc finger; ROS: reactive oxygen species; HILI: RNA-mediated gene silencing 2; SSC: spermatogonial stem cell.
|
29911897 |
2018 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The transcriptions of the proapoptotic genes, insulin-like growth factor binding protein 3 (IGFBP3) and BCL2-interacting killer (BIK), were suppressed by ZNF179 via its interaction with the promyelocytic leukemia zinc finger (PLZF) protein in astrocytes.
|
24788683 |
2015 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The variant t(11;17) translocation produces two fusion proteins, promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα) and RARα-PLZF, both of which participate in leukemia development.
|
23898169 |
2013 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
By using a murine leukemic model carrying both promyelocytic leukemia zinc finger/retinoic acid receptor-α (PLZF/RARα) and RARα/PLZF fusion genes, we discovered that 8-chlorophenylthio adenosine-3', 5'-cyclic monophosphate (8-CPT-cAMP) enhances cellular differentiation and improves gene trans-activation by ATRA in leukemic blasts.
|
23382200 |
2013 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (RARA) gene and the promyelocytic leukemia (PML) or promyelocytic leukemia zinc finger (PLZF) gene.
|
23208507 |
2013 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The promyelocytic leukemia zinc finger (PLZF) protein exerts neuroprotective effects in neuronal cells and is dysregulated in experimental stroke.
|
20731660 |
2011 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine whether the promyelocytic leukemia zinc finger (PLZF) protein, a transcriptional repressor and negative regulator during cell cycling, plays a role in the proliferation of cultured human corneal endothelial cells (HCECs).
|
17515885 |
2007 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As an approach to silencing estrogen-regulated genes, we have studied the activities of a fusion protein between ERalpha and the promyelocytic leukemia zinc-finger (PLZF) protein, a transcriptional repressor that acts through chromatin remodeling.
|
15647773 |
2005 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This phenotype is induced by specific acute myeloid leukemia-associated translocations, such as t(15;17) and t(11;17), which involve an identical portion of the retinoic acid receptor alpha (RARalpha) and either the promyelocytic leukemia (PML) or promyelocytic zinc finger (PLZF) genes, respectively.
|
16024608 |
2005 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The promyelocytic leukemia zinc finger (PLZF) protein has been described as a transcriptional repressor of homeobox (HOX)-containing genes during embryogenesis.
|
15077196 |
2004 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The silencing mediator of retinoic and thyroid hormone receptors (SMRT) corepressor mediates transcriptional repression by interacting with transcription factors such as the promyelocytic leukemia zinc finger (PLZF) protein.
|
14982881 |
2004 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report that the promyelocytic leukemia zinc finger (PLZF) protein can interact with GATA-2 and can modify its transactivation capacity.
|
11964310 |
2002 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HERV-K encodes a protein of the Rev/Rex family, cORF, that supports cellular transformation and binds the promyelocytic leukemia zinc finger (PLZF) protein implicated in spermatogenesis.
|
11287007 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we review how a detailed analysis of the functions of two of these RARalpha partners, the promyelocytic leukemia (PML) and promyelocytic leukemia zinc finger (PLZF) proteins, has allowed a greater understanding of the molecular mechanisms implicated in APL pathogenesis.
|
11561158 |
2001 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha.
|
10339585 |
1999 |
|
Promyelocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
FAZF is homologous to the promyelocytic leukemia zinc finger (PLZF) protein, which has been shown to act as a transcriptional repressor by recruitment of nuclear corepressors (N-CoR, Sin3, and HDAC1 complex).
|
10572087 |
1999 |
|
Promyelocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We and others have previously implicated the SMRT corepressor in the actions of the PLZF transcription factor and in the function of its oncogenic derivative, PLZF-retinoic acid receptor (RARalpha), in promyelocytic leukemia.
|
9765306 |
1998 |
|
Promyelocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We further characterized the genomic organization of the promyelocytic leukemia zinc finger (PLZF) gene that maps within the PGL1 critical region and physically excluded the serotonin receptor type 3 (5HT3R) gene.
|
9299238 |
1997 |