|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Objective To study the position of hemiplegic migraine in the clinical spectrum of migraine with aura and to reveal the importance of CACNA1A, ATP1A2 and SCN1A in the development of hemiplegic migraine in Finnish migraine families.
|
29486580 |
2018 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the α<sub>1A</sub> subunit of voltage-gated Ca<sub>V</sub>2.1 calcium channels.
|
27032388 |
2017 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Sixty patients with migraine without aura (MO) or with different types of migraine with aura (MA), including sporadic hemiplegic, familial hemiplegic, and probable familial hemiplegic, were screened for mutations in the four genes previously linked with different types of migraine (ATP1A2, CACNA1A, SCN1A, and KCNK18).
|
26747084 |
2016 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Glutamate has been implicated in cortical spreading depression (CSD), the phenomenon responsible for migraine with aura and in animal models carrying FHM mutations.
|
27423601 |
2016 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated CaV2.1 channels, are associated with familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of common migraine with aura.
|
24849341 |
2014 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Familial hemiplegic migraine type 1 (FHM-1) is an autosomal dominant form of migraine with aura characterized by recurrent migraine, hemiparesis and ataxia.
|
23430985 |
2013 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Familial hemiplegic migraine type 1 (FHM-1) is a monogenic form of migraine with aura that is characterized by recurrent attacks of a typical migraine headache with transient hemiparesis during the aura phase.
|
22549042 |
2012 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We now report on a mutation identified in the first intracellular loop of CACNA1A (alpha(1A(A454T))) that does not cause FHM but is associated with the absence of sensorimotor symptoms in a migraine with aura pedigree.
|
20080591 |
2010 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Newly characterised 5' and 3' regions of CACNA1A gene harbour mutations associated with Familial Hemiplegic Migraine and Episodic Ataxia.
|
18976783 |
2009 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Expansion of the phenotypic spectrum of the CACNA1A T666M mutation: a family with familial hemiplegic migraine type 1, cerebellar atrophy and mental retardation.
|
18279427 |
2008 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The CACNA1A and ATP1A2 genes are not involved in dominantly inherited migraine with aura.
|
16508934 |
2006 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Childhood epilepsy, familial hemiplegic migraine, cerebellar ataxia, and a new CACNA1A mutation.
|
15452324 |
2004 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The shared hemiplegic migraine phenotype of mutations in ATP1A2 and CACNA1A raises the possibility that they coordinately regulate ion homeostasis that determines susceptibility to the initiation of both migraine aura and the pain phase of migraine.
|
14624354 |
2004 |
|
Migraine with Aura
|
0.200 |
Biomarker
|
disease |
BEFREE |
Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels.
|
15003170 |
2004 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The discovery of mutations in the neural calcium channel (CACNA1A) gene in familial hemiplegic migraine (FHM), variant of migraine with aura, led to the suggestion that this gene might be involved in familial migraine with aura (FMA).
|
12111613 |
2002 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A susceptibility locus for migraine with aura has been located on chromosome 19 (but is distinct from CACNA1A) and a genome-wide linkage analysis has mapped a susceptibility locus on chromosome 4.
|
12849426 |
2002 |
|
Migraine with Aura
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, the CACNA1A gene encoding the brain-specific P/Q type calcium channel alpha(1) subunit, has been cloned and mutations in this gene, located on chromosome 19p13, have been shown to be involved in familial hemiplegic migraine (FHM), a rare autosomal dominantly inherited subtype of migraine with aura.
|
11719257 |
2002 |
|
Migraine with Aura
|
0.200 |
Biomarker
|
disease |
BEFREE |
Transmission disequilibrium testing provided no evidence for linkage of MA to CACNA1A.
|
12370474 |
2002 |
|
Migraine with Aura
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|