Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
These data suggest a role for MAPK1 and CACNA1C in MDD risk and treatment resistance, respectively.
|
31352702 |
2019 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.
|
30626913 |
2019 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5).
|
28989100 |
2018 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
CTD_human |
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression.
|
28696432 |
2018 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression.
|
28696432 |
2018 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder.
|
28497380 |
2017 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study provides support for positive association between CACNA1C and MDD; however, the current data suggest the necessity of replication analyses in a larger-scale sample.
|
27260792 |
2016 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia.
|
24411473 |
2014 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia.
|
24642287 |
2014 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in CACNA1C affects neural processing in major depression.
|
24612926 |
2014 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.
|
24262814 |
2014 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression.
|
23860750 |
2014 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.
|
24262814 |
2014 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Genetic variation in CACNA1C affects neural processing in major depression.
|
24612926 |
2014 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
Major Depressive Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese.
|
23680436 |
2013 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
A mega-analysis of genome-wide association studies for major depressive disorder.
|
22472876 |
2013 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51).
|
21042317 |
2012 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We were interested whether this also applies for ANK3 and CACNA1C and tested associations of single nucleotide polymorphisms (SNPs) in these genes with MDD in two Caucasian case-control samples.
|
22647524 |
2012 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
|
20351715 |
2011 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
|
20351715 |
2011 |
Major Depressive Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |