Disease: Intraocular pressure disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0595921
Disease: Intraocular pressure disorder
Intraocular pressure disorder 		0.020 Biomarker disease BEFREE Previously, we identified the calcium voltage-gated channel auxiliary subunit alpha2delta 1 gene (<i>Cacna2d1</i>) as a modulator of IOP and demonstrated that pregabalin, a drug with high affinity and selectivity for CACNA2D1, lowered IOP in a dose-dependent manner. 31714057 2019
CUI: C0595921
Disease: Intraocular pressure disorder
Intraocular pressure disorder 		0.020 Biomarker disease BEFREE Because our study utilizes a genetically diverse population of mice with known sequence variants, we are able to determine that the intraocular pressure-lowering effect of pregabalin is dependent on the Cacna2d1 haplotype. 29176626 2017