|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Here, we recapitulate the biosynthesis of polysialic acid by the two polysialyltransferases ST8SIA2 and ST8SIA4 and highlight the increasing evidence that variation in the human ST8SIA2 gene is linked to schizophrenia and possibly other neuropsychiatric disorders.
|
23354723 |
2013 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In contrast, no significant association was observed between any variations in SIAT8D and schizophrenia.
|
16229822 |
2006 |
|
Colorectal Carcinoma
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis shows that CYP2E1 Rsa I/Pst I and 96-bp insertion polymorphisms may be associated with CRC risk.
|
23355335 |
2013 |
|
Colorectal Carcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus.
|
29848360 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Tumour xenograft was created to explore the functions of HOTAIR and ST8SIA4 in tumorigenesis in vivo.
|
30105850 |
2018 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Furthermore stable expression of ST8SiaII-IB, ST8SiaIV-IB and luciferase in the rhabdomyosarcoma cell line TE671 reduced cell surface expression of polySia and delayed tumor growth if cells were xenografted into C57BL/6 J RAG-2 mice.
|
28499450 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The demonstration that polyST knock-down negates events associated with tumour cell dissemination indicates that PST and STX are validated targets.
|
22463390 |
2012 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The PST gene was constantly expressed in both normal lung tissue and tumor tissue of all cases.
|
10850459 |
2000 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Pst I restriction fragment length polymorphism of the human placental alkaline phosphatase gene in normal placentae and tumors.
|
2885837 |
1987 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The cytotoxicity of PST-PTX nanoparticles in cancer cell lines and resistant cancer cell lines were determined by MTT assay.
|
31201909 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
The cytotoxicity of PST-PTX nanoparticles in cancer cell lines and resistant cancer cell lines were determined by MTT assay.
|
31201909 |
2019 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Meta-analysis based on the eligible case-control studies that assess the association of CYP2E1 Rsa I/Pst I and Dra I polymorphisms with urinary cancer was conducted.
|
29156840 |
2017 |
|
Diabetes Mellitus
|
0.030 |
GeneticVariation
|
group |
BEFREE |
In a pilot randomized controlled trial, 40 participants with DR and diabetes distress were allocated to the PST-D or control groups.
|
28243448 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Meta-analysis based on the eligible case-control studies that assess the association of CYP2E1 Rsa I/Pst I and Dra I polymorphisms with urinary cancer was conducted.
|
29156840 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Multivariate analyses revealed association of tooth extraction with diabetes (P < .0001), smoking (P < .0001), and number of preventive visits (P = .004), but no support for the PST genetic test (P = .96) nor indication that the benefit of 2 preventive visits was affected by this genetic test (P = .58).
|
25726343 |
2015 |
|
Liver carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
CYP2E1 Pst I/Rsa I polymorphism may contribute to the proportion cases of HCC, which needs further investigations.
|
25185993 |
2014 |
|
Liver carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis indicated that CYP2E1 Pst I/Rsa polymorphism was not associated with HCC risk, while the interaction between Pst I/Rsa polymorphism and alcohol consumption increased the risk of HCC.
|
22249978 |
2012 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Comparative polymorphisms distribution, at position 14181 and 14201(intron 7), between HD and PST revealed a trend of association (p= 0.07) with cancer risk.
|
19414295 |
2009 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Comparative polymorphisms distribution, at position 14181 and 14201(intron 7), between HD and PST revealed a trend of association (p= 0.07) with cancer risk.
|
19414295 |
2009 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the human hepatoma cell line, HepG2, was used as a model to investigate the effect of antioxidant phenolic acids on enzymatic activity and expression of one of the major phase II sulfate conjugation enzymes, P-form phenolsulfotransferase (PST-P).
|
15941313 |
2005 |
|
Diabetes Mellitus
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We conclude that the Proinsulin Kyoto gene is not a common cause of DM and the occurrence of the alpha type insulin gene in Japanese diabetes is more frequent than in other races, so this Pst I polymorphism is not a marker for diabetes mellitus in Japanese.
|
7951555 |
1994 |
|
Mental Depression
|
0.020 |
Biomarker
|
disease |
BEFREE |
Findings provide further support for the utility of therapist-guided online F-PST in reducing parental depression and distress following pediatric traumatic brain injury and offer limited evidence of the efficacy of self-guided online treatment for these outcomes.
|
31033747 |
2020 |
|
Depressive disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
Findings provide further support for the utility of therapist-guided online F-PST in reducing parental depression and distress following pediatric traumatic brain injury and offer limited evidence of the efficacy of self-guided online treatment for these outcomes.
|
31033747 |
2020 |