TFEB, transcription factor EB, 7942

N. diseases: 150; N. variants: 16
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE Our results highlight the potential utility of suppressing TFEB-driven autophagy to block PC metastasis. 31387632 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 GeneticVariation phenotype BEFREE We report the high frequency of split signals by FISH in tumors with t(6;11) chromosomal rearrangement and the occurrence of TFEB gene copy number gains in the aggressive cases, analyzing either the primary or metastatic tumor. 29052596 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 GeneticVariation phenotype BEFREE Fourth, the TFEB-amplified RCC were associated with a more aggressive clinical course; 3 of 8 cases presented with advanced stage or metastatic disease, 2 subsequently developed metastatic disease, whereas the other 3 cases had minimal/no follow-up. 27565001 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE TFEB RCCs are predominantly seen in younger patients and are generally indolent, with only 2 cases of metastasis. 22173116 2012