|
Pharyngitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>IMPORTANCE</b> The human bacterial pathogen <i>Streptococcus pyogenes</i> (group A streptococcus [GAS]) causes more than 600 million cases of pharyngitis annually worldwide, 15 million of which occur in the United States.
|
29104937 |
2019 |
|
Amyloidosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Methods</b>: We screened targeting anti-Aβ <i>scFv</i> 12B4 and thermophilic acylpeptide hydrolase as amyloid-degrading enzyme, synthesized GAS gold nanorods complex.
|
31149043 |
2019 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo,</i> delaying Aβ-induced paralysis in AD model of <i>Caenorhabditis elegans</i> was also tested by GAS.
|
31149043 |
2019 |
|
Pharyngitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<i>Streptococcus pyogenes</i> (Group A <i>Streptococcus</i>; GAS) commonly causes pharyngitis in children and adults, with severe invasive disease and immune sequelae being an infrequent consequence.
|
29868516 |
2018 |
|
Pharyngitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>Streptococcus pyogenes</i> (group A streptococcus [GAS]) is a serious human pathogen with the ability to colonize mucosal surfaces such as the nasopharynx and vaginal tract, often leading to infections such as pharyngitis and vulvovaginitis.
|
31239377 |
2019 |
|
Vulvovaginitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
<i>Streptococcus pyogenes</i> (group A streptococcus [GAS]) is a serious human pathogen with the ability to colonize mucosal surfaces such as the nasopharynx and vaginal tract, often leading to infections such as pharyngitis and vulvovaginitis.
|
31239377 |
2019 |
|
Tonsillitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
<i>Streptococcus pyogenes</i> (Group A streptococcus; GAS) is a human pathogen causing diseases from uncomplicated tonsillitis to life-threatening invasive infections.
|
31092533 |
2019 |
|
Rheumatic Fever
|
0.050 |
Biomarker
|
disease |
BEFREE |
Rheumatic fever (RF) and rheumatic heart disease (RHD) are postinfectious complications of an infection (or repeated infection) with the Gram-positive bacterium, Streptococcus pyogenes (also known as group A streptococcus, GAS).
|
17172649 |
2006 |
|
Anthrax disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anthrax toxin-mediated delivery of NADase in an amount comparable to that observed during in vitro infection with live GAS rescued the defective intracellular survival of NADase-deficient GAS and increased the survival of SLO-deficient GAS.
|
26938870 |
2016 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Influenza A virus (IAV) and Streptococcus pyogenes (the group A Streptococcus; GAS) are important contributors to viral-bacterial superinfections, which result from incompletely defined mechanisms.
|
30108238 |
2018 |
|
Lactational amenorrhea
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Lactational amenorrhea is thought to be a risk factor for GAS vulvovaginitis.
|
31151810 |
2019 |
|
Influenza
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Influenza superinfections with GAS have been described to occur regularly and to show a severe clinical picture with high mortality.
|
31237087 |
2019 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
|
24260416 |
2013 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
|
24260416 |
2013 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GAS and ERBB2 protein expression was studied by Western immunoblotting from gastric cancer cell lines with or without gain at 17q12-q21 as well as a breast cancer cell line with ERBB2 amplification.
|
9892105 |
1999 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GAS and ERBB2 protein expression was studied by Western immunoblotting from gastric cancer cell lines with or without gain at 17q12-q21 as well as a breast cancer cell line with ERBB2 amplification.
|
9892105 |
1999 |
|
HER2 gene amplification
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GAS and ERBB2 protein expression was studied by Western immunoblotting from gastric cancer cell lines with or without gain at 17q12-q21 as well as a breast cancer cell line with ERBB2 amplification.
|
9892105 |
1999 |
|
Mastitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A custom-designed microarray containing 220 virulence genes of Streptococcus pyogenes (group A Streptococcus [GAS]) was used to test group C Streptococcus dysgalactiae subsp. dysgalactiae (GCS) field strains causing bovine mastitis and group C or group G Streptococcus dysgalactiae subsp. equisimilis (GCS/GGS) isolates from human infections, with the latter being used for comparative purposes, for the presence of virulence genes.
|
21525223 |
2011 |
|
Pharyngitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 135 GAS clinical strains were isolated from the tonsils of 116 pediatric patients with acute GAS pharyngitis between November, 2012 and April, 2014 in Saga, Japan.
|
30247119 |
2018 |
|
Skin Diseases, Infectious
|
0.020 |
Biomarker
|
group |
BEFREE |
Absence of Cas9 was linked to reduced GAS epithelial cell adherence, reduced growth in human whole blood <i>ex vivo</i>, and attenuation of virulence in a murine necrotizing skin infection model.
|
31507572 |
2019 |
|
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
All of them received GAS 914 along with different immunosuppression protocols.
|
15818319 |
2005 |
|
Meningitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although not common, GAS meningitis must be considered in children vaccinated for other invasive pathogens.
|
24177305 |
2013 |
|
Streptococcal toxic shock syndrome
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Among the 1542 invasive GAS strains studied, 78% (n=1206) were from blood cultures, and a streptococcal toxic shock syndrome (STSS) was described in 22% (n=340) of cases, mainly associated with necrotizing fasciitis (NF) and pleuro-pulmonary infections (p<0.001).The in-hospital fatality rate was 15%.
|
21883669 |
2012 |
|
Necrotizing fasciitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Among the 1542 invasive GAS strains studied, 78% (n=1206) were from blood cultures, and a streptococcal toxic shock syndrome (STSS) was described in 22% (n=340) of cases, mainly associated with necrotizing fasciitis (NF) and pleuro-pulmonary infections (p<0.001).The in-hospital fatality rate was 15%.
|
21883669 |
2012 |
|
Secondary malignant neoplasm of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among the transcripts of the genes studied, VEGFR-1, VEGFR-2, HIF-1alpha, uPA , and PA I-1 overexpression in tumor tissues was significantly associated with the presence of bone metastasis (p=0.02, p=0.02, p<0.0001, p=0.04, and p=0.03, respectively).
|
20544684 |
2010 |