|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
CGRP, known as the most potent vasodilator substance, plays an important role in hypertension initiation and development.
|
30818175 |
2019 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Calcitonin gene-related peptide (CGRP) can cause migraines, yet it is also a potent vasodilator that protects against hypertension.
|
29297736 |
2019 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
The present study investigated in a rat model of hypertension whether the high conductance at acupoints is a result of the release of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) during neurogenic inflammation in the referred pain area.
|
30618546 |
2018 |
|
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The present study investigates whether increased blood pressure in protein-restricted offspring would be associated with changes in the DRG cells and in renal pelvic wall expression of NK1R, SP and CGRP when compared to NP offspring.
|
28632750 |
2017 |
|
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, there is an up-regulation of cerebellar CGRP1 (CRLR + RAMP1) and AM2 (CRLR + RAMP3) receptors and a down-regulation of AM1 (CRLR + RAMP2) receptor during hypertension associated with a decreased AM expression.
|
27614623 |
2017 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
No significant differences were noted in the genotype distributions for AGTR1, PRRC2A, and CALCA polymorphisms in patients with hypertension (N = 500) and healthy controls (N = 506).
|
24338417 |
2013 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
By comparing results from a range of human and animal studies, findings broadly suggest an association between CGRP and the pathophysiology of hypertension in terms of protective mechanisms, with possibly the RAMP1 component of the CGRP receptor playing a key role in the brain stem, in addition to peripheral receptors.
|
21269690 |
2011 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide.
|
20375903 |
2010 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension.
|
19462497 |
2009 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Effect of prepro-calcitonin gene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension.
|
17643632 |
2007 |
|
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Association between the calcitonin-related peptide alpha (CALCA) gene and essential hypertension in Japanese subjects.
|
17485015 |
2007 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
We also discuss the effects of direct administration of CGRP in the treatment of hypertension and of anti-hypertensive drugs that enhance the release or response of endogenous calcitonin gene-related peptide: angiotensin converting enzyme inhibitors, selective antagonists for the angiotensin II receptor, beta-blockers, magnesium sulphate for preeclampsia and rutaecarpine, as well as the possibilities using CGRP in gene therapy for prevention of vasospasm after subarachnoid haemorrage.
|
16909931 |
2006 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse.
|
10694533 |
2000 |
|
Hypertensive disease
|
0.400 |
Therapeutic
|
group |
CTD_human |
We recently reported that calcitonin gene-related peptide (CGRP) reversed the hypertension induced by nitric oxide inhibition in pregnant rats and that this effect appeared to be progesterone dependent.
|
9887042 |
1999 |
|
Hypertensive disease
|
0.400 |
Therapeutic
|
group |
CTD_human |
The antihypertensive effect of calcitonin gene-related peptide in rats with norepinephrine- and angiotensin II-induced hypertension.
|
1849535 |
1991 |