|
Pancreatitis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Effects of PRSS1-PRSS2 rs10273639, CLDN2 rs7057398 and MORC4 rs12688220 polymorphisms on individual susceptibility to pancreatitis: A meta-analysis.
|
31163246 |
2020 |
|
Pancreatitis, Alcoholic
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.
|
28754779 |
2018 |
|
Pancreatitis, Alcoholic
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
In a much broader approach employing genome wide search strategies the NAPS study found that polymorphisms in the Trypsin locus (PRSS1 rs10273639), and the Claudin 2 locus (CLDN2-RIPPLY1-MORC4 locus rs7057398 and rs12688220) confer an increased risk of developing alcohol-induced pancreatitis.
|
26149858 |
2015 |
|
Pancreatitis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
|
23143602 |
2012 |
|
Male infertility
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Obstructive azoospermia
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Pancreatitis, Chronic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP.
|
29884332 |
2018 |
|
Pancreatitis, Chronic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Additionally all the SNPs confirmed statistically significant associations with risk of developing CP, the strongest being PRSS1-PRSS2-rs10273639 (OR<sub>heterozygous</sub> = 0.51, 95% CI 0.39-0.67, p = 1.10 × 10<sup>-6</sup> ) and MORC4-rs 12837024 (OR<sub>homozygous</sub> = 2.07 (1.55-2.77, p<sub>trend</sub> = 0.7 × 10<sup>-11</sup> ).
|
28913878 |
2018 |
|
Pancreatitis, Chronic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in CLDN2 and MORC4 genes were associated with CP in Indian patients.
|
26820620 |
2016 |
|
Pancreatitis, Chronic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1-PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2-MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4).
|
25253127 |
2015 |
|
Acute pancreatitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The results of pooled analyses showed that CLDN2 rs7057398, MORC4 rs12688220 and PRSS1-PRSS2 rs10273639 polymorphisms were all significantly associated with susceptibility to acute pancreatitis in Caucasians.
|
31163246 |
2020 |
|
Acute pancreatitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP.
|
29884332 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, restoration of miR-193b-3p expression in breast cancer cells led to decreased growth and activation of apoptosis, which was consistent with results associated with MORC4 silencing in breast cancer cells.
|
30320920 |
2019 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, restoration of miR-193b-3p expression in breast cancer cells led to decreased growth and activation of apoptosis, which was consistent with results associated with MORC4 silencing in breast cancer cells.
|
30320920 |
2019 |
|
Crohn Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that a variant of the CLDN2-MORC4 region predisposes to CD in a Swedish population.
|
23946598 |
2013 |
|
Inflammatory Bowel Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease.
|
23946598 |
2013 |
|
Hodgkin Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells.
|
17608765 |
2007 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.
|
17608765 |
2007 |
|
Adult Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells.
|
17608765 |
2007 |
|
Childhood Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells.
|
17608765 |
2007 |