|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Monocyte count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Monocyte count result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Alzheimer's Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
A Missense Variant in TREML2 Reduces Risk of Alzheimer's Disease in a Han Chinese Population.
|
26797517 |
2017 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our results showed that the AD-associated top immune genes reported in Europeans (CR1, CD33, CLU, and TREML2) have weak effects in Chinese, whereas CFH showed strong effects.
|
26243271 |
2016 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have linked variants in TREM2 (triggering receptor expressed on myeloid cells 2) and TREML2 with Alzheimer disease (AD) and AD endophenotypes.
|
25545807 |
2015 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Additionally, we demonstrate that the protective role of TREML2 in AD is independent of the role of TREM2 gene as a risk factor for AD.
|
24439484 |
2014 |
|
Hepatitis B
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We found rs2127015 of CD276, rs6915083 and rs7754593 of TREML2, and HBV infection as well were associated with acute rejection.
|
31044564 |
2019 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study first elucidated the mechanism by which TLT-2 influences the activation of CD8<sup>+</sup>T cells, improved the understanding of the TLT-2 signalling pathway and clarified the role of the TLT-2<sup>+</sup>CD8<sup>+</sup>T cell subset in hepatitis B virus infection.
|
30361846 |
2019 |
|
Ankylosing spondylitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results obtained for the AS pedigree and sporadic patients suggest that mutation of TREML2 is a major factor leading to AS for HLA-B27 (+) members in this large family and that TREML2 is also a susceptibility gene promoting the development of ankylosing spondylitis in HLA-B27 (+) individuals.
|
29778423 |
2018 |
|
Alzheimer Disease, Late Onset
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recently, Benitez and colleagues re-analyzed whole-exome sequencing data and revealed that a coding missense variant (rs3747742-C) in triggering receptor expressed on myeloid cells-like 2 (TREML2) gene reduced late-onset Alzheimer's disease (LOAD) risk in Caucasians.
|
26797517 |
2017 |
|
Hypertensive disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
|
24142389 |
2014 |
|
Inflammation
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation.
|
16670310 |
2006 |