|
Germ cell tumor
|
0.330 |
PosttranslationalModification
|
disease |
BEFREE |
Finally, methylation of CpGs in the NANOG promoter in germ cell tumors and derived cell lines correlated to differentiation state.
|
20930529 |
2011 |
|
Germ cell tumor
|
0.330 |
Biomarker
|
disease |
BEFREE |
The abundance of factors associated with pluripotency (NANOG and OCT-3/4) and undifferentiated state (AP-2gamma) may explain the remarkable pluripotency of germ cell neoplasms, which are capable of differentiating to various somatic tissue components of teratomas.
|
16540528 |
2006 |
|
Germ cell tumor
|
0.330 |
Biomarker
|
disease |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Germ cell tumor
|
0.330 |
Biomarker
|
disease |
BEFREE |
Identification of NANOG as a molecular marker of undifferentiated germ cell tumors provides a novel tool for identifying and classifying tumors of germ cell origin.
|
16206293 |
2005 |
|
Germ Cell Cancer
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Aberrant activation of the ES transcription factor network elicited by increased dosage of an embryonic gene cluster at 12p including NANOG, together with additional genetic and epigenetic alterations, appears to be a crucial event in the genesis of testicular germ cell cancers.
|
17965618 |
2008 |
|
Germ Cell Cancer
|
0.310 |
Biomarker
|
disease |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Neoplastic Cell Transformation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention.
|
29626521 |
2018 |
|
Embryonal Neoplasm
|
0.300 |
Biomarker
|
disease |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Neoplasms, Germ Cell and Embryonal
|
0.300 |
Biomarker
|
group |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Neoplasms, Embryonal and Mixed
|
0.300 |
Biomarker
|
disease |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Cancer, Embryonal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Cancer, Embryonal and Mixed
|
0.300 |
Biomarker
|
disease |
CTD_human |
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
|
16168501 |
2005 |
|
Malignant tumor of colon
|
0.260 |
Biomarker
|
disease |
BEFREE |
We observed that miR-147 was downregulated in several colon cancer cell lines, and overexpressed miR-147 decreased the expression of cancer stem cell (CSC) markers OCT4, SOX2, and NANOG in the colon cancer cell lines HCT116 and SW480.
|
29426374 |
2019 |
|
Malignant tumor of colon
|
0.260 |
GeneticVariation
|
disease |
BEFREE |
We found that both PHD3 and PHD3-H196A suppress the expression of the stem cell-associated gene NANOG and inhibited the properties of colon cancer stem cells through p53.
|
31092600 |
2019 |
|
Malignant tumor of colon
|
0.260 |
AlteredExpression
|
disease |
BEFREE |
We exposed human colon cancer HCT116 cells to repeated cycles of a chemotherapeutic agent - doxorubicin (doxo) and demonstrated induction of hallmarks of TIS (e.g. growth arrest, hypertrophy, poliploidization and secretory phenotype) and certain properties of cancer stem cells (increased NANOG expression, percentages of CD24+ cells and side population).
|
28030837 |
2017 |
|
Malignant tumor of colon
|
0.260 |
AlteredExpression
|
disease |
BEFREE |
The effects of pitavastatin on colon cancer stem cells were studied using the colorimetric MTT cell proliferation assay; quantitative polymerase chain reaction was used to determine the expression of cell cycle genes, OCT4, SOX2, and NANOG; Western blots were performed to measure MDR1.
|
28387909 |
2017 |
|
Malignant tumor of colon
|
0.260 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of B4GALNT3 using small interfering (si) RNAs in colon cancer cell lines (HCT116, SW480, HCT15, and HT29 cells) decreased sphere formation and the expression of stem cell markers, OCT4 and NANOG.
|
25003232 |
2014 |
|
Malignant tumor of colon
|
0.260 |
Biomarker
|
disease |
BEFREE |
A pro-metastatic role of NANOG in colon cancer cells was also demonstrated, using a NANOG-overexpressing orthotopic tumor implantation mouse model.
|
24023739 |
2013 |
|
Malignant tumor of colon
|
0.260 |
Therapeutic
|
disease |
RGD |
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
|
22641368 |
2012 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
NANOGP8, a retro-pseudogene of stem cell mediator NANOG, is expressed predominantly in cancer cells and plays a role in tumorigenesis.
|
31626853 |
2020 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NANOG is an essential transcriptional factor for the maintenance of embryonic stem cells (ESCs) and cancer stem cells (CSCs) in prostate cancer (PCa).
|
30595535 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On this basis, we investigated the role of NANOG protein expression as an early cancer risk biomarker in oral potentially malignant disorders (OPMD), and the impact on prognosis and disease outcomes in OSCC patients.
|
31484317 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hypoxia also enhanced the expression of cancer stem cell (CSC) transcription factors (NANOG, Oct4, SOX2), CD133 and EMT markers (N-cadherin, Vimentin), thereby supporting invasion.
|
31634481 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis.
|
31619256 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We observed that miR-147 was downregulated in several colon cancer cell lines, and overexpressed miR-147 decreased the expression of cancer stem cell (CSC) markers OCT4, SOX2, and NANOG in the colon cancer cell lines HCT116 and SW480.
|
29426374 |
2019 |