|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
MED28 increases the colony-forming ability of breast cancer cells by stabilizing the ZNF224 protein upon DNA damage.
|
29435049 |
2018 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
MED28 increases the colony-forming ability of breast cancer cells by stabilizing the ZNF224 protein upon DNA damage.
|
29435049 |
2018 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
MED28 Regulates Epithelial-Mesenchymal Transition Through NFκB in Human Breast Cancer Cells.
|
27662245 |
2017 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
MED28 Regulates Epithelial-Mesenchymal Transition Through NFκB in Human Breast Cancer Cells.
|
27662245 |
2017 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
CTD_human |
Our data indicate that resveratrol modulates the effect of MED28 on cellular migration, presumably through the EGFR/phosphatidylinositol 3-kinase (PI3K) signaling pathway, in breast cancer cells.
|
21942447 |
2011 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Our data indicate that resveratrol modulates the effect of MED28 on cellular migration, presumably through the EGFR/phosphatidylinositol 3-kinase (PI3K) signaling pathway, in breast cancer cells.
|
21942447 |
2011 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
Transfection experiments which overexpressed the full-length EG-1 gene in human embryonic kidney HEK-293 cells or human breast cancer cell lines resulted in significantly increased in vitro proliferation, in comparison with transfection with empty vectors.
|
16024617 |
2005 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Transfection experiments which overexpressed the full-length EG-1 gene in human embryonic kidney HEK-293 cells or human breast cancer cell lines resulted in significantly increased in vitro proliferation, in comparison with transfection with empty vectors.
|
16024617 |
2005 |
|
Mammary Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells.
|
21942447 |
2011 |
|
Mammary Neoplasms
|
0.310 |
Biomarker
|
group |
LHGDN |
Targeted inhibition of EG-1 blocks breast tumor growth.
|
17568184 |
2007 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells.
|
21942447 |
2011 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells.
|
21942447 |
2011 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells.
|
21942447 |
2011 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Our data indicate that MED28 interacts with FOXM1, and each affects the expression and localization of the other, and, more importantly, both regulate MMP2-dependent migration and invasion in human lung cancer cells.
|
30499104 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Our laboratory has also reported that MED28 regulates cell growth, migration, and invasion in human breast cancer cells.
|
26660958 |
2016 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, ectopic expression of MEK1 rescued the inhibitory effect of MED28 knockdown on invasion, and exogenous MMP2 recombinant protein recovered the suppression on invasion upon MED28 or MEK1 knockdown.
|
22495818 |
2012 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The mammalian mediator complex subunit 28 (MED28) is overexpressed in a variety of cancers and it regulates cell migration/invasion and epithelial-mesenchymal transition.
|
30970566 |
2019 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
MED28, a mammalian Mediator subunit, was found highly expressed in several types of malignancy, including breast cancer.
|
27662245 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of the current study is to investigate the potential role of MED28 and FOXM1 in NSCLC.
|
30499104 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
MED28, a mammalian Mediator subunit, was found highly expressed in several types of malignancy, including breast cancer.
|
27662245 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the current study we investigated the effect of ATRA on MED28 and Wnt/β-catenin signaling in colorectal cancer.
|
26660958 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the current study we investigated the effect of ATRA on MED28 and Wnt/β-catenin signaling in colorectal cancer.
|
26660958 |
2016 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Previously, we have shown that the expression of EG-1 is significantly elevated in the epithelial cells of breast cancer, colorectal cancer, and prostate cancer.
|
16024617 |
2005 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Previously, we have shown that the expression of EG-1 is significantly elevated in the epithelial cells of breast cancer, colorectal cancer, and prostate cancer.
|
16024617 |
2005 |