Stage IV Skin Melanoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.
|
12110844 |
2002 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
A survey of 135 polymorphisms in 23 genes identified the ADAM33 gene as being significantly associated with asthma using case-control, transmission disequilibrium and haplotype analyses (P = 0.04 0.000003).
|
12110844 |
2002 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification and characterization of ADAM33, a putative asthma susceptibility gene identified by positional cloning in an outbred population, should provide insights into the pathogenesis and natural history of this common disease.
|
12110844 |
2002 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recent study has identified the variation in the ADAM33 gene as an important risk factor for asthma.
|
12401189 |
2002 |
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The human Adam33 gene is located on chromosome 20p13, a region that has been linked to asthma and bronchial hyperresponsiveness.
|
12768445 |
2003 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the polymorphisms in Adam33 have been found to be associated with asthma.
|
12768445 |
2003 |
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The identification of ADAM33 as a major risk factor involved in the pathogenesis of BHR and airway wall remodelling provides insight into the pathogenesis of asthma and represents a novel therapeutic target.
|
12885268 |
2003 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of ADAM33 as a major risk factor involved in the pathogenesis of BHR and airway wall remodelling provides insight into the pathogenesis of asthma and represents a novel therapeutic target.
|
12885268 |
2003 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans.
|
12958057 |
2003 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine whether polymorphisms in ADAM33 are associated with asthma or closely related phenotypes in 4 different asthma populations.
|
14564349 |
2003 |
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Eight single nucleotide polymorphisms (SNPs) were evaluated in the 3' portion of ADAM33 in 4 unique asthma populations (African American, US white, US Hispanic, and Dutch white).
|
14564349 |
2003 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined whether polymorphisms in ADAM33 are associated with asthma and related traits in two German populations.
|
14720258 |
2004 |
Hyperactive behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The ADAM33 gene has recently been associated with asthma and bronchial hyper-reactivity.
|
14720258 |
2004 |
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic variation in ADAM33 is strongly associated with asthma and bronchial hyperresponsiveness.
|
14742294 |
2004 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of those isoforms of ADAM33 that are expressed in airways is fundamental to dissecting the role of ADAM33 in asthma.
|
14742294 |
2004 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, further support for ADAM33 (the first asthma susceptibility gene identified by positional cloning) as an asthma gene was presented, although with mixed results.
|
14764626 |
2004 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In physiology the identification of the ADAM33 gene as an asthma susceptibility gene has led to a new hypothesis concerning the pathogenesis of asthma.
|
15007338 |
2004 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.
|
15144468 |
2004 |
Hyperactive behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling.
|
15144468 |
2004 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess whether genetic variants of ADAM33 are related to asthma in a Korean population, we conducted an association study of the ADAM33 gene with asthma susceptibility, bronchial hyper-reactivity and serum IgE in Korean asthmatics (n=326) and normal controls (n=151).
|
15196271 |
2004 |
Hyperactive behavior
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
To assess whether genetic variants of ADAM33 are related to asthma in a Korean population, we conducted an association study of the ADAM33 gene with asthma susceptibility, bronchial hyper-reactivity and serum IgE in Korean asthmatics (n=326) and normal controls (n=151).
|
15196271 |
2004 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Seventeen ADAM33 single nucleotide polymorphisms (SNPs; including 9 associated with asthma in the initial report) were genotyped by mass spectrometry.
|
15208587 |
2004 |
Childhood asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ADAM33 polymorphisms and phenotype associations in childhood asthma.
|
15208587 |
2004 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A recent report provided evidence that a disintegrin and metalloprotease domain 33 (ADAM33), a member of the ADAM family, is a novel susceptibility gene in asthma linked to bronchial hyper-responsiveness.
|
15298558 |
2004 |