|
Stage IV Skin Melanoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.
|
12110844 |
2002 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recent study has identified the variation in the ADAM33 gene as an important risk factor for asthma.
|
12401189 |
2002 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
A survey of 135 polymorphisms in 23 genes identified the ADAM33 gene as being significantly associated with asthma using case-control, transmission disequilibrium and haplotype analyses (P = 0.04 0.000003).
|
12110844 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification and characterization of ADAM33, a putative asthma susceptibility gene identified by positional cloning in an outbred population, should provide insights into the pathogenesis and natural history of this common disease.
|
12110844 |
2002 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The identification of ADAM33 as a major risk factor involved in the pathogenesis of BHR and airway wall remodelling provides insight into the pathogenesis of asthma and represents a novel therapeutic target.
|
12885268 |
2003 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The human Adam33 gene is located on chromosome 20p13, a region that has been linked to asthma and bronchial hyperresponsiveness.
|
12768445 |
2003 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine whether polymorphisms in ADAM33 are associated with asthma or closely related phenotypes in 4 different asthma populations.
|
14564349 |
2003 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans.
|
12958057 |
2003 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of ADAM33 as a major risk factor involved in the pathogenesis of BHR and airway wall remodelling provides insight into the pathogenesis of asthma and represents a novel therapeutic target.
|
12885268 |
2003 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Eight single nucleotide polymorphisms (SNPs) were evaluated in the 3' portion of ADAM33 in 4 unique asthma populations (African American, US white, US Hispanic, and Dutch white).
|
14564349 |
2003 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the polymorphisms in Adam33 have been found to be associated with asthma.
|
12768445 |
2003 |
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic variation in ADAM33 is strongly associated with asthma and bronchial hyperresponsiveness.
|
14742294 |
2004 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The potential for therapeutic intervention with ADAM 33 is extremely attractive and further work will not only focus on the specific domains of ADAM 33, but also the mechanisms by which they lead to bronchial hyperreactivity.
|
15347848 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A recent report provided evidence that a disintegrin and metalloprotease domain 33 (ADAM33), a member of the ADAM family, is a novel susceptibility gene in asthma linked to bronchial hyper-responsiveness.
|
15298558 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In physiology the identification of the ADAM33 gene as an asthma susceptibility gene has led to a new hypothesis concerning the pathogenesis of asthma.
|
15007338 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
ADAM33 might play a key role in predisposing to the reduced lung function characteristic of asthma, possibly by influencing airway wall remodelling.
|
15387895 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Seventeen ADAM33 single nucleotide polymorphisms (SNPs; including 9 associated with asthma in the initial report) were genotyped by mass spectrometry.
|
15208587 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined whether polymorphisms in ADAM33 are associated with asthma and related traits in two German populations.
|
14720258 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.
|
15144468 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of those isoforms of ADAM33 that are expressed in airways is fundamental to dissecting the role of ADAM33 in asthma.
|
14742294 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAM33 might play a key role in predisposing to the reduced lung function characteristic of asthma, possibly by influencing airway wall remodelling.
|
15387895 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess whether genetic variants of ADAM33 are related to asthma in a Korean population, we conducted an association study of the ADAM33 gene with asthma susceptibility, bronchial hyper-reactivity and serum IgE in Korean asthmatics (n=326) and normal controls (n=151).
|
15196271 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma.
|
15347848 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, further support for ADAM33 (the first asthma susceptibility gene identified by positional cloning) as an asthma gene was presented, although with mixed results.
|
14764626 |
2004 |