Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We assessed the familial correlation of PRO-C3 concentration, the shared gene effects between PRO-C3 concentration and liver steatosis and fibrosis, and the association between PRO-C3 concentration and genetic variants in the patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane-bound O-acyltransferase domain-containing (MBOAT), and glucokinase regulator (CGKR) genes.
|
30859582 |
2019 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
NAFLD predisposition runs strongly in families and an allele in the PNPLA3 gene has shown a strong association with liver steatosis and hepatic inflammation.
|
21178608 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Compared to recipients with only the PNPLA3 GG allele or obesity (defined as body mass index > 25 kg/m(2)), steatosis was highly prevalent (71.4%) in PNPLA3 GG carriers with obesity.
|
26379412 |
2015 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A nonsynonymous single nucleotide polymorphism rs738409 (rs738409" genes_norm="80339">I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) predisposes susceptibility to NAFLD; however, its association with steatosis grade is inconsistent in the literature.
|
23176674 |
2012 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conducted a meta-analysis to assess the association between patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) and its subtypes simple steatosis(SS) and nonalcoholic steatohepatitis (NASH).
|
25791171 |
2015 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
75 (42.4%) patients tested positive for a PNPLA3 minor/major risk allele (G/C:66; G/G:9) showed comparable fibrosis stages (median F2 vs. F2; p = 0.292) and similar amounts of hepatic steatosis (CAP: 203.5 ± 41.9 vs. 215.5 ± 59.7 dB/m; p = 0.563) as compared to patients without a PNPLA3 risk allele.
|
26599080 |
2015 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A genetic variant in adiponutrin (PNPLA3) gene, rs738409 C/G, is associated with steatosis, severity, and progression of liver fibrosis in CHC patients, and predicts treatment outcome in difficult-to-cure HCV-infected patients with advanced fibrosis.
|
26389885 |
2015 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Establishment and characterization of an iPSC line from a 58 years old high grade patient with nonalcoholic fatty liver disease (70% steatosis) with homozygous wildtype PNPLA3 genotype.
|
30081348 |
2018 |
Steatohepatitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We used real-time polymerase chain reaction (PCR) analysis to analyze the hepatic expression of PNPLA3 and lipid metabolism-related genes in 55 morbidly obese subjects with normal liver histology (NL, n = 18), simple steatosis (SS, n = 20), and non-alcoholic steatohepatitis (NASH, n = 17).
|
27128907 |
2016 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In Italian and United Kingdom patients, adiponutrin genotype influenced alanine aminotransferase levels and the severity of steatosis.
|
20373368 |
2010 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Frequencies of allele PNPLA3 rs738409(G) in individuals with steatosis and normal alanine aminotransferase (ALT) and AST levels were lower than in alcoholics without steatosis and normal ALT/AST (P(combined) = 0.03).
|
21254164 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a case only analysis of G allele of rs738409 in PNPLA3 was associated with a decreased risk of zone 3 centered steatosis (OR = 0.46, 95% CI = 0.36-0.58; P = 5.15 x 10(-11)).
|
20648472 |
2010 |
Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
PNPLA3 may be an important key to understand the mechanisms discriminating fatty liver with and without metabolic consequences.
|
19651814 |
2009 |
Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recent studies have implicated PNPLA3 in the pathogenesis of hepatic steatosis.
|
20480550 |
2010 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from steatosis, chronic hepatitis, cirrhosis and ultimately to HCC.
|
23333103 |
2013 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A common variant in PNPLA3 increases the risk of hepatic steatosis in humans.
|
19224197 |
2009 |
Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The PNPLA3 p.148 I/M or M/M variants and CD4(+) cell count were the only independent predictors of severe steatosis in patients with HCV non-3 genotypes.
|
26806136 |
2016 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer.
|
29116096 |
2017 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 rs738409[G] allele was significantly correlated with severe steatosis (P = 0.04), severe fibrosis at the time of enrollment (P = 0.0005) and fibrosis progression with an OR of 10.31 (95% CI 1.06 - 99.59, P = 0.04), after a mean follow-up time of 62.85 (95%CI: 52.21 - 76.15) months.
|
31642820 |
2019 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Regarding the latter, a sequence variation within the gene coding for patatin-like phospholipase encoding 3 (PNPLA3, rs738409) was found to modulate steatosis, necroinflammation and fibrosis in NAFLD.
|
22110053 |
2012 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 p.148M/M genotype was negatively associated with SVR and early viral kinetics independently of steatosis, albeit only in difficult-to-cure G1/4 patients with advanced fibrosis, whereas stratification for the p.148M/M PNPLA3 genotype unmasked an association between IL28B CC genotype and more severe liver fibrosis.
|
22530607 |
2012 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, IL28B rs12979860 and PNPLA3 rs738409 modify steatosis.
|
26259026 |
2016 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis.
|
25250621 |
2014 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multivariate logistic regression identified PNPLA3 G allele (OR: 2.469, CI 95%: 1.203-5.068; p=0.014) and pediatric age (OR: 4.348; 1.577-11.905; p=0.004) as independent variables associated with moderate/severe steatosis.
|
25678388 |
2015 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis pooled four studies with 1135 cases of chronic hepatitis B (CHB) to evaluate the impact of PNPLA3 SNP on liver steatosis and also pooled five studies with 3713 cases of CHB to evaluate the impact of PNPLA3 SNP on cirrhosis.
|
29218813 |
2018 |