Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
PNPLA3 may be an important key to understand the mechanisms discriminating fatty liver with and without metabolic consequences.
|
19651814 |
2009 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A common variant in PNPLA3 increases the risk of hepatic steatosis in humans.
|
19224197 |
2009 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In Italian and United Kingdom patients, adiponutrin genotype influenced alanine aminotransferase levels and the severity of steatosis.
|
20373368 |
2010 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a case only analysis of G allele of rs738409 in PNPLA3 was associated with a decreased risk of zone 3 centered steatosis (OR = 0.46, 95% CI = 0.36-0.58; P = 5.15 x 10(-11)).
|
20648472 |
2010 |
Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recent studies have implicated PNPLA3 in the pathogenesis of hepatic steatosis.
|
20480550 |
2010 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After adjustment for age, sex, diabetes, and alcohol consumption, the minor allele of rs738409 C/G, a nonsynonymous coding SNP in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene encoding an rs738409" genes_norm="80339">Ile148Met change, was associated with steatosis (P = 0.03), portal inflammation (P = 2.5 x 10(-4)), lobular inflammation (P = 0.005), Mallory-Denk bodies (P = 0.015), NAFLD activity score (NAS, P = 0.004), and fibrosis (P = 7.7 x 10(-6)).
|
20684021 |
2010 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In multivariate logistic regression, the relationship between the highest quartile of CIMT and steatosis was different according to adiponutrin polymorphism.
|
20826584 |
2010 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A common variant of the PNPLA3 gene confers susceptibility to hepatic steatosis in obese youths without increasing the level of hepatic and peripheral insulin resistance.
|
20803499 |
2010 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the PNPLA3 gene rs738409" genes_norm="80339">I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults.
|
20546964 |
2010 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
NAFLD predisposition runs strongly in families and an allele in the PNPLA3 gene has shown a strong association with liver steatosis and hepatic inflammation.
|
21178608 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Frequencies of allele PNPLA3 rs738409(G) in individuals with steatosis and normal alanine aminotransferase (ALT) and AST levels were lower than in alcoholics without steatosis and normal ALT/AST (P(combined) = 0.03).
|
21254164 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A recent finding that a nonsynonymous polymorphism in the PNPLA3 gene predicts the extent of steatosis in NAFLD has been replicated in at least eight studies, with several studies also demonstrating an association with fibrosis.
|
21476920 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide association study identified genetic polymorphism (rs738409 C>G) in the PNPLA3/adiponutrin gene associated with liver steatosis.
|
21334404 |
2011 |
Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although African Americans are less susceptible to fatty liver than European Americans, PNPLA3 appears to be a risk locus for hepatic steatosis in diabetic African Americans.
|
21665509 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rs738409 SNP in PNPLA3 is associated with an increased risk of steatosis in patients infected with HCV genotypes non-3.
|
21236304 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rs738409 PNPLA3 genotype influences steatosis development in CHC and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly HCC.
|
21319195 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (rs738409" genes_norm="80339">p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis.
|
22087248 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We studied the influence of rs738409 and other variants in the PNPLA3 region on steatosis and fibrosis assessed both in a cross-sectional and longitudinal manner.
|
21488075 |
2011 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A nonsynonymous single nucleotide polymorphism rs738409 (rs738409" genes_norm="80339">I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) predisposes susceptibility to NAFLD; however, its association with steatosis grade is inconsistent in the literature.
|
23176674 |
2012 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Regarding the latter, a sequence variation within the gene coding for patatin-like phospholipase encoding 3 (PNPLA3, rs738409) was found to modulate steatosis, necroinflammation and fibrosis in NAFLD.
|
22110053 |
2012 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 p.148M/M genotype was negatively associated with SVR and early viral kinetics independently of steatosis, albeit only in difficult-to-cure G1/4 patients with advanced fibrosis, whereas stratification for the p.148M/M PNPLA3 genotype unmasked an association between IL28B CC genotype and more severe liver fibrosis.
|
22530607 |
2012 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls.
|
22898488 |
2012 |
Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL28B and PNPLA3 are associated with hepatic steatosis prevalence and severity in Caucasians with G1 HCV, suggesting differing potential genetic risk pathways to steatosis.
|
22543885 |
2012 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3, but not the APOC3 rs2854116 SNP, was associated with fatty liver but not with triglyceride levels.
|
22105854 |
2012 |
Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP), the rs738409, in the patatin like phospholipase 3 gene (PNPLA3) has been recently associated with increased hepatic steatosis and ALT levels in adults and children.
|
22629460 |
2012 |