|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development.
|
24114809 |
2014 |
|
Liver Cirrhosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Among nine studies, with 2,937 patients, PNPLA3 was associated with increased risk of HCC in patients with cirrhosis (OR 1.40, 95% CI 1.12-1.75).
|
24445574 |
2014 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.
|
23535911 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Homozygous carriers of the PNPLA3 variant are prone to develop cirrhosis in the absence of other risk factors such as alcohol or viral hepatitis.
|
24222094 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
According to ultrasound examinations, no association between PNPLA3 rs738409 genotype and fatty change of the liver or hepatic cirrhosis was found in Japanese patients infected with HCV.
|
24349054 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In ALD&NAFLD patients, the PNPLA3 148M allele was associated with younger age, shorter history of cirrhosis, less advanced (Child A) cirrhosis at HCC diagnosis, and lower HCC differentiation grade (p<0.05).
|
24155878 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 rs738409 genotypes were assessed in 279 patients with alcoholic- and 253 patients with HCV-related cirrhosis.
|
23069476 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, 1 patient with NAFLD-related cirrhosis was compound heterozygous for rare damaging mutations in PNPLA3.
|
24081230 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 GG genotype was significantly associated with underlying cirrhosis in HCC patients (OR = 2.48; 95% CI, 1.05-5.87).
|
23776098 |
2013 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The -1195GG genotype of single nucleotide polymorphism (SNP) in COX-2 promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409 C>G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance.
|
22863264 |
2012 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis.
|
22719190 |
2012 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previous studies of the PNPLA3 I148M sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis, and cirrhosis.
|
22978414 |
2012 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis.
|
22560221 |
2012 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Whether the PNPLA3 rs738409 polymorphism could be a risk factor for the development of hepatocellular carcinoma (HCC) in cirrhosis patients is unknown.
|
21745286 |
2011 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of note, the PNPLA3 risk variant advances fibrosis in the total cohort as well as in the subgroups of patients with viral hepatitis and non-viral liver diseases and contributes 16% of the total cirrhosis risk.
|
21168459 |
2011 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease.
|
21334404 |
2011 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The rs738409 PNPLA3 genotype influences steatosis development in CHC and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly HCC.
|
21319195 |
2011 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We compared distributions of PNPLA3 genotypes in 80 and 81 Caucasian patients with alcoholic and hepatitis C virus (HCV)-associated HCC to 80 and 81 age- and sex-matched patients with alcohol-related and HCV-related cirrhosis without HCC, respectively.
|
22087248 |
2011 |
|
Liver Cirrhosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The population attributable risk of cirrhosis in alcoholic carriers of allele PNPLA3 rs738409(G) was estimated at 26.6%.
|
21254164 |
2011 |