|
Liver Cirrhosis, Alcoholic
|
0.500 |
Biomarker
|
disease |
BEFREE |
In line, sera from PNPLA3 148M-positive patients with alcoholic liver cirrhosis contained higher levels of interleukin-8 and CXCL1 than patients with wild-type PNPLA3.
|
31637480 |
2019 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although no single variant reached genome-wide significance, an association signal was observed for PNPLA3 rs738409 (p = .01, OR 1.9, 95% CI 1.1-3.1), a common single nucleotide polymorphism that has been associated with a variety of liver-related pathologies including alcoholic cirrhosis.
|
28776448 |
2017 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 rs738409 and TM6SF2 rs58542926 variants increase the risk of hepatocellular carcinoma in alcoholic cirrhosis.
|
26493626 |
2016 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 genetic polymorphism (rs738409 C>G) is associated with increased risk for the entire spectrum of ALD among drinkers including ALI, AC, and HCC.
|
25964223 |
2015 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
|
26482880 |
2015 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
|
26482880 |
2015 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
Biomarker
|
disease |
BEFREE |
PNPLA3 10109G predisposed North Indian subjects to alcoholic cirrhosis.
|
24114820 |
2014 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 rs738409" genes_norm="80339">I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis.
|
24102786 |
2014 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis.
|
25060292 |
2014 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Since, alcoholic CP and ALC share the same aetiology PNPLA3 variant (p.I148M) possibly influences the development of alcoholic CP.
|
22276112 |
2012 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotype PNPLA3 rs738409(GG) is associated with alcoholic liver cirrhosis and elevated aminotransferase levels in alcoholic Caucasians.
|
21254164 |
2011 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.
|
22087248 |
2011 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)).
|
19946271 |
2010 |
|
Liver Cirrhosis, Alcoholic
|
0.500 |
Biomarker
|
disease |
CTD_human |
We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)).
|
19946271 |
2010 |