|
Adult Craniopharyngioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results revealed B7-H3 was highly expressed in CPs and targeting B7-H3 might therefore be an effective therapeutic strategy against craniopharyngioma.
|
31043272 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study highlights B7-H3 as a viable target in MB angiogenesis, and that the expression of miR-29 can inhibit B7-H3 and sensitize MB cells to treatment with MYC-inhibiting drugs.
|
31382461 |
2019 |
|
Malignant Bone Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
This review summarized the studies on B7-H3 in bone cancers.
|
31060912 |
2019 |
|
Lupus Erythematosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we analyzed the serum expression of B7-H3 in 113 rheumatoid arthritis and systemic lupus erythematous patients using the ELISA and found a positive correlation between B7-H3 and VEGF.
|
31292886 |
2019 |
|
Ewings sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two studies investigated the possibility to treat Ewing`s sarcoma through targeting the B7-H3 CAR (chimeric antigen receptors) T-cells or using anti-B7-H3 antibody.
|
31060912 |
2019 |
|
Malignant neoplasm of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
The anti-apoptotic effect on cancer-associated fibroblasts of B7-H3 molecule enhancing the cell invasion and metastasis in renal cancer.
|
31213832 |
2019 |
|
Acute GVH disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, we found that + 7 days B7H1/B7H3 serum levels can predict grade III-IV aGVHD, while only the + 7 days B7H1 serum level, together with viral infection and donor age, could independently predict GRM in patients with haplo-HSCT.
|
30725359 |
2019 |
|
Gestational Trophoblastic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
PD-L1 and B7-H3 were highly expressed in all GTN tumours, while PD-L2 was expressed in 87.5% of the samples.
|
31013360 |
2019 |
|
Trophoblastic tumor, epithelioid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PD-L1, B7-H3 and VISTA levels were significantly higher in choriocarcinomas and PSTTs than in ETTs.
|
31013360 |
2019 |
|
Renal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The anti-apoptotic effect on cancer-associated fibroblasts of B7-H3 molecule enhancing the cell invasion and metastasis in renal cancer.
|
31213832 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, soluble B7H3 was elevated in plasma of patients with idiopathic pulmonary fibrosis and in BAL fluid in those with acute exacerbation.
|
31106564 |
2019 |
|
IMMUNE SUPPRESSION
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Meanwhile, tumor-derived CCR1<sup>+</sup> CD14<sup>+</sup> monocytes expressed significantly higher levels of programmed cell death-ligand 1, B7-H3, and T-cell immunoglobulin domain and mucin domain-3 that may lead to immune suppression.
|
30070719 |
2019 |
|
Low grade glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results indicated that B7-H3 was positively stained in most of the clinical glioma samples, and its expression levels were correlated to the malignancy grade and poor survival in both low-grade glioma (LGG) and GBM patients.
|
31485480 |
2019 |
|
Congenital heart disease in children
|
0.010 |
Biomarker
|
disease |
BEFREE |
Relationship Between Serum B7-H3 Levels and Prognosis of Congenital Heart Disease in Children.
|
30328478 |
2019 |
|
Phyllodes Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Stromal B7-H3 messenger RNA and protein expression were noted in 10 (16.7%) and 31 (51.7%) of 60 benign phyllodes tumors, 12 (46.1%) and 20 (76.9%) of 26 borderline phyllodes tumors, and 10 (66.7%) and 13 (86.7%) of 15 malignant phyllodes tumors, respectively.
|
30486739 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
This result suggests that B7-H3 may be may be a promising biomarker associated with the pathogenesis of T1D.
|
30081105 |
2018 |
|
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggested that B7-H3 might contribute to the progression of HBV infection by triggering inhibitory signals in effector T cells and it was closely associated with the progression and poor prognosis during HBV infection.
|
30481143 |
2018 |
|
HIV Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Case-control study of PD-1, PD-L1 and B7-H3 expression in lung cancer patients with and without human immunodeficiency virus (HIV) infection.
|
30089601 |
2018 |
|
Central Nervous System Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Higher B7-H3 expression indicates a worse prognosis for glioma patients, which warrants further research into the development of inhibitors for targeting this immune checkpoint, but we still need to be cautious about immune checkpoint inhibition for central nervous system tumors.
|
30027617 |
2018 |
|
Complete atrioventricular block
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The B7-H3 expression was positively correlated with aspartate aminotransferase and alanine aminotransferase levels in CHB and sB7-H3 level was higher in late tumor/node/metastasis (TNM) stage in HCC.
|
30481143 |
2018 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of miR-29c/B7-H3 axis in children with allergic asthma.
|
30075787 |
2018 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, B7-H3 is involved in the development and progression of cervical intraepithelial neoplasia and cervical cancer through its effects on the cell cycle and apoptosis, which are mediated via the E7/Rb pathway.
|
30087701 |
2018 |
|
stage, pancreatic cancer
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
B7-H3 expression may be a useful prognostic biomarker for identifying aggressive early-stage pancreatic cancer.
|
29996538 |
2018 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that B7-H3 may be a valuable biomarker in determining tumor progression and prognosis of intrahepatic cholangiocarcinoma.
|
29696716 |
2018 |
|
Squamous cell carcinoma of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PD-L1, B7-H3, and PD-1 expression in immunocompetent vs. immunosuppressed patients with cutaneous squamous cell carcinoma.
|
29484464 |
2018 |