SPX, spexin hormone, 80763

N. diseases: 33; N. variants: 0
Disease: Cystic Fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.050 Biomarker disease BEFREE We have developed SPX-101 to replace the lost function of SPLUNC1 in the CF lung. 29936069 2019
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.050 Biomarker disease BEFREE First clinical trials of novel ENaC targeting therapy, SPX-101, in healthy volunteers and adults with cystic fibrosis. 31302339 2019
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.050 Biomarker disease BEFREE Unlike SPLUNC1, the novel SPLUNC1-derived peptide SPX-101 resisted protease degradation, bound apically to HBECs, inhibited ENaC and prevented ASL dehydration following extended pre-incubation with CF sputum.Our data indicate that CF mucosal secretions drive ASL hyperabsorption and that protease-resistant peptides, <i>e.g.</i> SPX-101, can reverse this effect to rehydrate CF ASL. 30190268 2018
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.050 Biomarker disease BEFREE Nonclinical safety assessment of SPX-101, a novel peptide promoter of epithelial sodium channel internalization for the treatment of cystic fibrosis. 28984146 2017
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.050 Biomarker disease BEFREE ENaC internalization by SPX-101 in primary human bronchial epithelial cells from healthy and CF donors was assessed by surface biotinylation and subsequent Western blot analysis. 28481660 2017