|
Obesity
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
SPX level is closely associated with cardiovascular risk factors such as age, obesity, hypertension, and diabetes; however, its physiological significance in the cardiovascular system remains mostly undefined.
|
31396649 |
2020 |
|
Obesity
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We studied the levels of serum SPX in 40 obese and 32 normal weight pre-puberty children (mean age was 8.59 ± 1.82 and 8.15 ± 2.03 years in obesity and control groups respectively).
|
30673665 |
2019 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
The aim of this case-control study was to compare fasting serum spexin concentrations between normal weight (NW) and overweight/obese (OB/OW) adolescent females and explore the relationship between circulating spexin and anthropometric, bone and fat mass, metabolic and hormonal parameters.
|
31810188 |
2019 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
Spexin, a novel peptide, has potential implications in obesity, satiety and energy homeostasis.
|
29045048 |
2018 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
Both, SPX and KISS could be therefore relevant in the pathophysiology of obesity and insulin resistance.
|
29137471 |
2018 |
|
Obesity
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In summary, SPX levels modestly affect glucose and insulin sensitivity in pregnant women but is not associated with GDM and obesity.
|
29740234 |
2018 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
The purpose of the current study was to determine the effect of obesity and type 2 diabetes (T2DM), and the effect of glucose ingestion on circulating spexin concentration in adolescents.
|
28626942 |
2018 |
|
Obesity
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Our aim was to measure spexin levels in lean type 1 diabetic patients and its relevance to glycemic parameters without the presence of obesity or insulin resistance.
|
30184546 |
2018 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
Incubation with spexin directly inhibited LCFA uptake by hepatocytes isolated from DIO mice with HS/NAFLD by ≤70%.
|
27997977 |
2016 |
|
Diabetes
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
SPX level is closely associated with cardiovascular risk factors such as age, obesity, hypertension, and diabetes; however, its physiological significance in the cardiovascular system remains mostly undefined.
|
31396649 |
2020 |
|
Diabetes Mellitus
|
0.050 |
AlteredExpression
|
group |
BEFREE |
SPX level is closely associated with cardiovascular risk factors such as age, obesity, hypertension, and diabetes; however, its physiological significance in the cardiovascular system remains mostly undefined.
|
31396649 |
2020 |
|
Cystic Fibrosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
We have developed SPX-101 to replace the lost function of SPLUNC1 in the CF lung.
|
29936069 |
2019 |
|
Cystic Fibrosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
First clinical trials of novel ENaC targeting therapy, SPX-101, in healthy volunteers and adults with cystic fibrosis.
|
31302339 |
2019 |
|
Cystic Fibrosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Unlike SPLUNC1, the novel SPLUNC1-derived peptide SPX-101 resisted protease degradation, bound apically to HBECs, inhibited ENaC and prevented ASL dehydration following extended pre-incubation with CF sputum.Our data indicate that CF mucosal secretions drive ASL hyperabsorption and that protease-resistant peptides, <i>e.g.</i> SPX-101, can reverse this effect to rehydrate CF ASL.
|
30190268 |
2018 |
|
Diabetes
|
0.050 |
Biomarker
|
disease |
BEFREE |
Further studies are necessary to determine whether SPX is associated with harder outcomes such as atherosclerosis and diabetes in the general population.
|
30254709 |
2018 |
|
Diabetes
|
0.050 |
Biomarker
|
disease |
BEFREE |
Spexin is a novel hormone involved in obesity and diabetes while its biofunctional significance in lipid metabolism is still to be comprehended.
|
29692737 |
2018 |
|
Diabetes
|
0.050 |
Biomarker
|
disease |
BEFREE |
The effects of spexin on insulin secretion in vitro and in vivo and also on cells viability and proliferation confirm that this peptide may be strongly involved in the pathogenesis of diabetes or its recovery.
|
29912854 |
2018 |
|
Diabetes
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Regression models, including age and diabetes duration, revealed no association between age and spexin levels.
|
30184546 |
2018 |
|
Diabetes Mellitus
|
0.050 |
Biomarker
|
group |
BEFREE |
The effects of spexin on insulin secretion in vitro and in vivo and also on cells viability and proliferation confirm that this peptide may be strongly involved in the pathogenesis of diabetes or its recovery.
|
29912854 |
2018 |
|
Diabetes Mellitus
|
0.050 |
Biomarker
|
group |
BEFREE |
Spexin is a novel hormone involved in obesity and diabetes while its biofunctional significance in lipid metabolism is still to be comprehended.
|
29692737 |
2018 |
|
Diabetes Mellitus
|
0.050 |
Biomarker
|
group |
BEFREE |
Further studies are necessary to determine whether SPX is associated with harder outcomes such as atherosclerosis and diabetes in the general population.
|
30254709 |
2018 |
|
Diabetes Mellitus
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Regression models, including age and diabetes duration, revealed no association between age and spexin levels.
|
30184546 |
2018 |
|
Cystic Fibrosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Nonclinical safety assessment of SPX-101, a novel peptide promoter of epithelial sodium channel internalization for the treatment of cystic fibrosis.
|
28984146 |
2017 |
|
Cystic Fibrosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
ENaC internalization by SPX-101 in primary human bronchial epithelial cells from healthy and CF donors was assessed by surface biotinylation and subsequent Western blot analysis.
|
28481660 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
To study the effect of Roux-en-Y gastric bypass (RYGB) surgery on endogenous spexin concentration and various risk factors of type 2 diabetes and cardiovascular disease in youth with severe obesity.
|
30131311 |
2018 |