|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Serum levels of major pro-angiogenic [Vascular endothelial growth factor (VEGF), Basic fibroblast growth factor (b-FGF)] and anti-angiogenic [Thrombospondin-1 (TSP-1), Endostatin] factors were identified by enzyme-linked immunosorbent assay and correlated with liver diseases progression and outcomes of HCC patients undergoing transarterial chemo-embolization.
|
31235729 |
2019 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
It may be concluded that Endostar inhibited immunity-associated angiogenesis behaviors of vascular endothelial cells in response to HCC.
|
29467868 |
2018 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Antitumor activities of Liver-targeting peptide modified Recombinant human Endostatin in BALB/c-nu mice with Hepatocellular carcinoma.
|
29075040 |
2017 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although sorafenib was approved as antiangiogenic agent in case of hepatocellular carcinoma (HCC), the pathways mediating its antitumorigenic effects were not fully examined in vivo.
|
27085325 |
2017 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, the only clinically approved systemic antiangiogenic agent for advanced HCC is sorafenib, which exerts considerable toxicity.
|
26278330 |
2015 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In vivo study of the effect of combining endostatin gene therapy with 32P-colloid on hepatocarcinoma and its functioning mechanism.
|
26416054 |
2015 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Results showed that the mutant rES-CSP reduce the stability and loss of function, and the wild-type rES-CSP could both bind to the normal liver cells Chang's and the hepatoma cells HepG2 but significantly higher than non-targeted rEndostatin. rESCSP could inhibit the proliferation of hepatoma cells in a dose-dependent manner, and increase the proportion of G1 phase, reduce the proportion of S phase, promote the apoptosis on hepatoma cells.
|
25731590 |
2015 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that COL18A1 rs7499 may contribute to the risk of HCC in Han Chinese.
|
22461898 |
2012 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Endostar, a modified recombinant human endostatin, exhibits synergistic effects with dexamethasone on angiogenesis and hepatoma growth.
|
21216091 |
2011 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings strongly suggest that berberine is a potential antiangiogenic agent and a promising antitumor drug for HCC.
|
21175812 |
2011 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Adenoviruses encoding antiangiogenic factors (pigment epithelium-derived factor and endostatin) or cytokines (GM-CSF and IL-12) were delivered via the hepatic artery separately or in combination into woodchuck livers bearing HCCs.
|
20679198 |
2010 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, previous studies have not examined the use of cord blood CD34+ cells as endostatin-producing cells for gene therapy against hepatoma.
|
19069638 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to explore the contribution of different doses of Endostar (endostatin, YH-16) on autophagic death in human hepatocellular carcinoma cells.
|
20443695 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to determine whether endostatin, a potent antiangiogenic agent, could enhance the efficacy of doxorubicin to combat HCC.
|
17627616 |
2007 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
In conclusion, increased endostatin/collagen XVIII expression correlated with hepatoma progression and predicted poor prognosis for patients with hepatocellular carcinoma.
|
15605080 |
2005 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
HCC cell line Hep3B was infected with recombinant adeno-associated virus containing human endostatin gene (rAAV2-hEndo).
|
15948234 |
2005 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The combination of local endostatin gene therapy with radiation therapy significantly inhibited the growth of human liver carcinoma BEL7402 xenografts, the inhibition rate of tumor size was 69.8% on d 28 compared to the untreated group.
|
16038050 |
2005 |
|
Liver carcinoma
|
0.300 |
ModifyingMutation
|
disease |
RGD |
In conclusion, combined expression of sFlt-1 and endostatin effectively suppresses HCC growth under in vivo conditions.
|
15739185 |
2005 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
By the tissue culture infectious dose 50 (TCID50) method and cytoviability assay, the replicative and cytolytic capabilities of CNHK300-mE in two HCC lines (HepGII and Hep3B) and one normal cell line (MRC-5) were analyzed, and the transgene expressions of mouse endostatin in vitro and in vivo were detected by Western blotting and ELISA assay.
|
15740644 |
2005 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To enhance its efficiency, CNHK200-mE, another E1B 55kDa-deficient adenovirus armed with a mouse endostatin gene was constructed and its antitumoral activities against hepatocellular carcinoma (HCC) in vitro and in vivo were investigated.
|
15389517 |
2005 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, increased endostatin/collagen XVIII expression correlated with hepatoma progression and predicted poor prognosis for patients with hepatocellular carcinoma.
|
15605080 |
2005 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Combined gene therapy of endostatin and interleukin 12 with polyvinylpyrrolidone induces a potent antitumor effect on hepatoma.
|
15259064 |
2004 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Endostatin gene therapy mediated by a recombinant adenoviral vector had significantly inhibited the growth of hepatocellular carcinoma BEL-7402 xenografted tumors at a high dose of 1 x 10(9) pfu compared with other groups.
|
15603709 |
2004 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
High level expression of endostatin gene was detected in the infected HCC BEL-7402 cells.
|
15222025 |
2004 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Treatment of colorectal and hepatocellular carcinomas by adenoviral mediated gene transfer of endostatin and angiostatin-like molecule in mice.
|
15016752 |
2004 |