|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss also led to earlier onset of disease in a separate TCL1-Tg-driven lymphoma model.
|
26522720 |
2016 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we assessed the protein levels of AID splice isoforms by introducing an AID splice reporter construct into cell lines and primary CLL cells from patients as well as from WT and TCL1(tg) C57BL/6 mice (where TCL1 is T-cell leukemia/lymphoma 1).
|
24668151 |
2014 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The inhibition of Hsp70 significantly reduced the growth of lymphoma xenografts in vivo and down-regulated the expression of Tcl1 protein.
|
23160471 |
2013 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The assembly of a collection of gene-expression signatures of the major types of B-cell non-Hodgkin's lymphoma has identified increased T-cell leukemia/lymphoma 1A (TCL1) expression in multiple lymphoma types and cases, and has enabled the investigation of the functional and clinical importance of TCL1 expression.
|
18820675 |
2009 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Combined, these results implicate epigenetic silencing of Spry2 expression in B lymphoma progression and suggest it as a companion lesion to ectopic TCL1 expression in enhancing MAPK-ERK pathway signaling.
|
19147787 |
2009 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
LHGDN |
MicroRNA losses in the frequently deleted region of 7q in SMZL.
|
17625607 |
2007 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Repression of TCL1 in GC B cells facilitates FAS-mediated apoptosis and prevents lymphoma formation.
|
17548807 |
2007 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Elevated T-cell leukemia-1 (TCL1) oncoprotein expression might promote human Burkitt lymphoma (BL) because increased TCL1 causes Burkitt-like lymphomas in TCL1 transgenic mice.
|
16146820 |
2005 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
LHGDN |
Tcl1 as a model for lymphomagenesis.
|
15325703 |
2004 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines.
|
12672960 |
2003 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
|
12381789 |
2002 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data indicate that the pattern of Tcl1 expression is distinct between naïve/GC and post-GC-derived B lymphomas (P < 0.001) and that the developmental pattern of expression is largely retained.
|
11304575 |
2001 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Paraffin-embedded tissue sections of lymphoma specimens were subjected to TCL1 immunohistochemistry, and positivity was scored on a three-tiered scale: - (< 25% cells), + (25-50% cells), and ++ (> 50% cells).
|
10792782 |
2000 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aberrant TCL1 expression has been implicated in T cell leukemia/lymphoma development, and its expression also has been seen in many established B cell tumor lines.
|
10449776 |
1999 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas.
|
7809072 |
1994 |