TCL1A, T cell leukemia/lymphoma 1A, 8115

N. diseases: 106; N. variants: 2
Disease: Leukemogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 AlteredExpression disease BEFREE Par-4 overexpression impedes leukemogenesis in the Eµ-TCL1 leukemia model through downregulation of NF-κB signaling. 30987970 2019
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Finally, we show that <i>Tet2</i> deficiency accelerates and exacerbates T-cell leukemia/lymphoma 1A-induced leukemogenesis. 29581109 2018
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE TCL1 plays a central role in lymphomagenesis as a co-activator of AKT kinases and other recently elucidated interacting protein partners. 30151355 2018
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss also led to earlier onset of disease in a separate TCL1-Tg-driven lymphoma model. 26522720 2016
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 GeneticVariation disease BEFREE Further, enhanced expression of the chemokine Ccl3, the oncogenic transcription factor Foxm1 and its targets in TCL1 Tg mice were significantly suppressed in the double Tg mice, suggesting a protective function of PTPROt against leukemogenesis. 25482129 2015
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice. 24379361 2014
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Deletion of CD44 during TCL1-driven murine leukemogenesis reduced the tumor burden in peripheral blood and spleen and led to a prolonged overall survival. 23547049 2013
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Herein, we review our recent study using this TCL1-driven mouse model for CLL and corresponding human CLL samples in a cross-species epigenomics approach to address the timing and relevance of epigenetic events occurring during leukemogenesis. 19901553 2009
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 AlteredExpression disease BEFREE Signaling via cAMP-inducible pathways inhibited TCL1 repression and reduced apoptosis, consistent with a prosurvival role for TCL1 before GC selection and supporting an initiating role for aberrant TCL1 expression during GC lymphomagenesis. 17548807 2007
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Tcl1 as a model for lymphomagenesis. 15325703 2004
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 GeneticVariation disease BEFREE Since the TCL6 gene was expressed in T-cell leukemia carrying a t(14;14)(q11;q32.1) chromosome translocation and was not expressed in normal T-cells (just like the TML1 and TCL1 genes), it is also a candidate gene potentially involved in leukemogenesis.Oncogene (2000). 10851082 2000
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Because of its location and sequence similarity with TCL1 and MTCP1 oncoproteins, this gene, named TML1 (TCL1/MTCP1-like 1) is a candidate gene that is potentially involved in leukemogenesis. 10344735 1999