|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that the oncogenic TRA-TCL1A/MTCP1 rearrangements in T-PLL occur during opening of the TRA locus, that is, during the progression from CD4+ immature single positive to early double positive thymocyte stage, just before physiologic TCL1A expression is silenced.
|
31677197 |
2020 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We formulate a multi-dimensional model of T-PLL pathogenesis centered around a unique combination of TCL1 overexpression with damaging ATM aberrations as initiating core lesions.
|
29449575 |
2018 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparison of karyotyping, <i>TCL1</i> fluorescence in situ hybridisation and TCL1 immunohistochemistry in T cell prolymphocytic leukaemia.
|
28821581 |
2018 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
T Cell Leukemia/Lymphoma 1A is expressed during B-cell differentiation and, when over-expressed, acts as an oncogene in mouse (Tcl1a) and human (TCL1A) B-cell chronic lymphocytic leukemia (B-CLL) and T-cell prolymphocytic leukemia (T-PLL).
|
30286151 |
2018 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This case demonstrates that hematogones can express TCL-1, and this knowledge is very important for the differential diagnosis in the follow-up marrow of T-PLL patients.
|
28232160 |
2017 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most common cytogenetic abnormality associated with T-PLL is inv(14)(q11.2q32) involving TCL1, but other abnormalities also have been reported.
|
28194886 |
2017 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The hallmark of T-PLL is the rearrangement of chromosome 14 involving genes for the subunits of the T-cell receptor (TCR) complex, leading to overexpression of the proto-oncogene TCL1.
|
29262669 |
2017 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The primary genetic alteration in T-PLL are the inv(14)(q11q32)/t(14;14)(q11;q32) leading to TRD/TRA-TCL1A fusion, or the t(X;14)(q28;q11) associated with TRD/TRA-MTCP1 fusion.
|
26917488 |
2016 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both had involvement of the bone marrow and peripheral blood but were morphologically unlike T-PLL and lacked TCL1 gene rearrangement.
|
26379148 |
2015 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell prolymphocytic leukemia (T-PLL) is an aggressive post-thymic T-cell malignancy characterized by the recurrent inv(14)(q11q32)/t(14;14)(q11;q32) or t(X;14)(q28;q11) leading to activation of either the TCL1 or MTCP1 gene, respectively.
|
24446122 |
2014 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequent MYC, ATM, and TCL1A alterations identified support that these genes are integral to the pathogenesis of T-PLL.
|
25310835 |
2014 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
T-cell leukemia/lymphoma 1 (TCL1) is an oncogene overexpressed in T-cell prolymphocytic leukemia and in B-cell malignancies including B-cell chronic lymphocytic leukemia and lymphomas.
|
23160471 |
2013 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In summary, a substantial number of T-PLL cases in Japan had abnormal expression of TCL1A, probably due to rearrangement of TCL1 region.
|
22189846 |
2012 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, and its rearrangement in T cells causes T-cell prolymphocytic leukemias.
|
22065599 |
2012 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The TCL1a oncoprotein is expressed in approximately 70% of T-PLL cases.
|
21505955 |
2011 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition.
|
19480937 |
2009 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High-level TCL1 in TCR-expressing T-PLL is associated with higher presenting white blood cell counts, faster tumor cell doubling, and enhanced in vitro growth response to TCR engagement.
|
17890451 |
2008 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
T-cell prolymphocytic leukemia (T-PLL) is consistently associated with inactivation of the ATM gene and chromosomal re-arrangements leading to an overexpression of MTCP1/TCL1 oncoproteins.
|
18073348 |
2008 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
LHGDN |
We propose that in T-PLL, TCL1 represents a highly regulated, targetable modulator of TCR-mediated AKT growth signaling.
|
17890451 |
2008 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
T-cell prolymphocytic leukaemia (T-PLL) is a sporadic, mature T-cell disorder in which there is usually an aberrant T-cell receptor alpha (TCRA) rearrangement that activates the TCL1 or MTCP1-B1 oncogenes.
|
11054065 |
2000 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chromosomal rearrangements observed in T-cell prolymphocytic leukemia involve the translocation of one T-cell receptor gene to either chromosome 14q32 or Xq28, deregulating the expression of cellular protooncogenes of unknown function, such as TCL1 or its homologue, MTCP1.
|
10786666 |
2000 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The study of T-cell chronic lymphocytic leukemias and T-cell prolymphocytic leukemia has led to the identification of TCL1, a novel gene that is deregulated by translocations, t(14;14)(q11;q32), or inversions, inv(14)(q11;q32.1).
|
10197596 |
1999 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature T-cell leukemia associated with chromosomal rearrangements implicating MTCP1 or TCL1 genes.
|
9657733 |
1998 |
|
T-Cell Prolymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MTCP1 putative oncogenes, respectively.
|
8634440 |
1996 |