|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
While many studies have assessed the predictive value of secreted phosphoprotein (SPP) genes in cancer, the findings have been inconsistent.
|
31849319 |
2019 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
IGF2 mRNA-binding protein 1 (IMP1) is a key regulator of messenger RNA (mRNA) metabolism and transport in organismal development and, in cancer, its mis-regulation is an important component of tumour metastasis.
|
30864660 |
2019 |
|
Primary malignant neoplasm
|
0.080 |
AlteredExpression
|
group |
BEFREE |
IGF2 mRNA-binding protein 1 (IMP1) is a key regulator of messenger RNA (mRNA) metabolism and transport in organismal development and, in cancer, its mis-regulation is an important component of tumour metastasis.
|
30864660 |
2019 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
While many studies have assessed the predictive value of secreted phosphoprotein (SPP) genes in cancer, the findings have been inconsistent.
|
31849319 |
2019 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
IMP1 is frequently overexpressed in cancer and is strongly correlated with a poor prognosis and reduced survival in melanoma, ovarian, breast, colon, and lung cancer.
|
28846937 |
2017 |
|
Primary malignant neoplasm
|
0.080 |
AlteredExpression
|
group |
BEFREE |
IMP1 is frequently overexpressed in cancer and is strongly correlated with a poor prognosis and reduced survival in melanoma, ovarian, breast, colon, and lung cancer.
|
28846937 |
2017 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity.
|
24931165 |
2015 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Interestingly, stromal deletion of Imp1 (Dermo1Cre;Imp1(LoxP/LoxP), or Imp1(ΔMes)) in the azoxymethane/dextran sodium sulfate (AOM/DSS) model of colitis-associated cancer resulted in increased tumor numbers of larger size and more advanced histologic grade than controls.
|
26194191 |
2015 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity.
|
24931165 |
2015 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
Interestingly, stromal deletion of Imp1 (Dermo1Cre;Imp1(LoxP/LoxP), or Imp1(ΔMes)) in the azoxymethane/dextran sodium sulfate (AOM/DSS) model of colitis-associated cancer resulted in increased tumor numbers of larger size and more advanced histologic grade than controls.
|
26194191 |
2015 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
The most differentially expressed gene was SPP (osteopontin), a secreted glycophosphoprotein which is known to be involved in cancer metastasis.
|
22797548 |
2012 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
The most differentially expressed gene was SPP (osteopontin), a secreted glycophosphoprotein which is known to be involved in cancer metastasis.
|
22797548 |
2012 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Cellular invasive activity of IMP-1 on mammalian cells was examined using Matrigel assays. mRNAs associated with IMP-1 in cancer cells were also isolated by RNA immunoprecipitation followed by cDNA microarray analysis.
|
17255263 |
2007 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
Cellular invasive activity of IMP-1 on mammalian cells was examined using Matrigel assays. mRNAs associated with IMP-1 in cancer cells were also isolated by RNA immunoprecipitation followed by cDNA microarray analysis.
|
17255263 |
2007 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
These data 1) suggest a normal role for CRD-BP/IMP1 in pluripotent stem cells with high renewal capacity, like the CB CD34(+) cells, 2) indicate that altered methylation may directly or indirectly affect its expression in adult cells, 3) imply that its de novo activation in cancer cells may affect the expression of c-Myc and insulin-like growth factor II, and 4) indicate that the inhibition of CRD-BP/IMP1 expression might affect cancer cell proliferation.
|
15769738 |
2005 |
|
Primary malignant neoplasm
|
0.080 |
AlteredExpression
|
group |
BEFREE |
These data 1) suggest a normal role for CRD-BP/IMP1 in pluripotent stem cells with high renewal capacity, like the CB CD34(+) cells, 2) indicate that altered methylation may directly or indirectly affect its expression in adult cells, 3) imply that its de novo activation in cancer cells may affect the expression of c-Myc and insulin-like growth factor II, and 4) indicate that the inhibition of CRD-BP/IMP1 expression might affect cancer cell proliferation.
|
15769738 |
2005 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
Finally, the author discusses the potential of SPP inhibitors for hepatitis C therapy.
|
28820612 |
2017 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
Treatment with this SPP inhibitor suppressed the maturation of core proteins of all HCV genotypes without the emergence of drug-resistant viruses, in contrast to the treatment with direct-acting antivirals.
|
29187532 |
2017 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
These data suggest that HCV utilizes SPP cleavage to circumvent the induction of ER stress in host cells.
|
27142248 |
2016 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
Of the 13 presenilin inhibitors tested, LY411575 was the most potent inhibitor of SPP-dependent cleavage of HCV core protein.
|
27797115 |
2016 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
The HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about residue 177 to generate the mature core protein (a.a. 1-177) and the cleaved peptide (a.a. 178-191).
|
24966583 |
2014 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
Finally, our nuclear magnetic resonance (NMR) structural analysis of a synthetic HCV JFH1 GT2a core-E1 signal peptide provides an essential structural template for a further understanding of core processing as well as the first model for an SPP substrate within its membrane environment.
|
22593157 |
2012 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Meanwhile, binding of IMP1 prevents the association of miR-122-5p with UCA1, thereby shifting the availability of miR-122-5p from UCA1 to the target mRNAs and reducing the UCA1-mediated cell invasion.
|
29669595 |
2018 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients.Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion.
|
28799908 |
2017 |