|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
Biomarker
|
disease |
BEFREE |
Homozygous and compound heterozygous missense and nonsense mutations in the poliovirus receptor related-4 (PVRL4) gene, encoding cell adhesion molecule nectin-4, have been identified as causal for EDSS1.
|
29265343 |
2018 |
|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
GeneticVariation
|
disease |
BEFREE |
Ectodermal dysplasia syndactyly syndrome (EDSS1) is one of the rare forms of ED caused by mutations in nectin-4, encoded by the PVRL4 gene.
|
25529316 |
2015 |
|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
GeneticVariation
|
disease |
BEFREE |
The involvement of mutant nectin-4 in causing EDSS1 may open up interesting prospectives into the role of cell adhesion molecules in causing syndromic forms of EDs.
|
21346770 |
2011 |
|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
GermlineCausalMutation
|
disease |
ORPHANET |
The involvement of mutant nectin-4 in causing EDSS1 may open up interesting prospectives into the role of cell adhesion molecules in causing syndromic forms of EDs.
|
21346770 |
2011 |
|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome.
|
20691405 |
2010 |
|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome.
|
20691405 |
2010 |
|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome.
|
20691405 |
2010 |
|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME 1
|
0.730 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Ectodermal Dysplasia
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
A novel homozygous missense variant in NECTIN4 (PVRL4) causing ectodermal dysplasia cutaneous syndactyly syndrome.
|
29430627 |
2018 |
|
Ectodermal Dysplasia
|
0.130 |
Biomarker
|
disease |
BEFREE |
In particular, nectin-1 mutations cause cleft lip/palate ED (CLPED1; OMIM#225060), whereas defective nectin-4 is associated with ED-syndactyly syndrome (EDSS1; OMIM#613573).
|
24577405 |
2014 |
|
Ectodermal Dysplasia
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
The involvement of mutant nectin-4 in causing EDSS1 may open up interesting prospectives into the role of cell adhesion molecules in causing syndromic forms of EDs.
|
21346770 |
2011 |
|
Ectodermal Dysplasia
|
0.130 |
Biomarker
|
disease |
HPO |
|
|
|
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nectin-4 was overexpressed at all stages of metastasis and angiogenesis, thus appearing to play a major role in tumor relapse through the PI3K-Akt-NFκβ pathway.
|
31617074 |
2020 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, Nectin-4 represents a potential target in TNBC, and its role in molecular defined breast cancer subtype should be investigated in larger patient cohorts.
|
31572728 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our present data unveiled that Nectin-4 played an important role in tumor biology and could serve as a useful prognostic predictor of human EC.
|
31043861 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We also assessed the relation between the expression level of NECTIN4 and the clinicopathological features of PTC in The Cancer Genome Atlas database, and results showed that upregulated NECTIN4 is associated with lymph node metastasis (<i>P</i><0.001) and tumor size (<i>P</i>=0.017).
|
31114323 |
2019 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, Nectin-4 represents a potential target in TNBC, and its role in molecular defined breast cancer subtype should be investigated in larger patient cohorts.
|
31572728 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4.
|
30056265 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of Nectin-4 was closely associated with differentiation (P=0.004), primary tumor (P=0.001), lymph node metastasis (P<0.001) and tumor-node-metastasis (TNM) stage (P<0.001).
|
29805618 |
2018 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4.
|
30056265 |
2018 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analysed nectin-4/PVRL4 mRNA expression in 5673 invasive breast cancers and searched for correlations with clinicopathological features including metastasis-free survival (MFS).
|
27998973 |
2017 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The current study provides clear evidence that Nectin-4 is a BCSC marker and is responsible for breast cancer metastasis.
|
28600142 |
2017 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed that MeV uptake was dynamin independent in the Vero.hPVRL4, Vero.hSLAM, and PVRL4-positive MCF7 breast cancer cell lines.
|
28250131 |
2017 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ADAM (<u>a</u><u>d</u>isintegrin <u>a</u>nd <u>m</u>etalloproteinase) proteases are involved in ectodomain cleavage of transmembrane proteins, and ADAM17 is known to cleave Nectin-4 in breast cancer.
|
28232483 |
2017 |