Disease: Diabetic Retinopathy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.020 AlteredExpression disease BEFREE The results of the present study revealed that miR-204-5p downregulated the expression of LC3B-II to inhibit autophagy in DR. 30936964 2019
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.020 AlteredExpression disease BEFREE The expression of BCL2 was increased, while the levels of caspase3 and LC3B were reduced through GLP-1 treatment in DR<i>.</i> GLP-1 treatment restored the GLP-1R expression and decreased the levels of phosphorylated AKT and phosphorylated ERK1/2, which was accompanied with the reduction of the HDAC6 levels in DR. <b>Conclusions:</b> GLP-1 treatment can alleviate autophagy which may be induced by oxidative stress; this protective effect is likely through GLP-1R-ERK1/2-HDAC6 signaling pathway. 29104476 2017