CAPN2, calpain 2, 824

N. diseases: 87; N. variants: 4
Disease: Cataract due to diabetes mellitus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011876
Disease: Cataract due to diabetes mellitus
Cataract due to diabetes mellitus 		0.010 GeneticVariation disease BEFREE Here we review recent studies, which in addition to the latter enzyme, have linked calpain 5, calpain 3, and its splice variants, calpain 2 and calpain 1 to T2DM-related metabolic pathways along with T2DM-associated phenotypes, such as obesity and impaired insulin secretion, and T2DM-related complications, such as epithelial dysfunction and diabetic cataract. 17151322 2006