|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
HPO |
|
|
|
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.350 |
FusionGene
|
disease |
ORPHANET |
|
|
|
|
Acute Myeloid Leukemia, M1
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Acute Myeloid Leukemia (AML-M2)
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Somatic mutation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> Phosphatidylinositol binding clathrin assembly protein (<i>PICALM</i>) rs541458 C allele has been identified and validated to be associated with a reduction of Alzheimer's disease (AD) risk.
|
31133980 |
2019 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
Familial lichen amyloidosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
63) associated nominally significantly with posterior AD, and rs3851179 at the PICALM locus had significant association with PCA (p = 0.0003, OR = 2.84).
|
24670887 |
2014 |
|
MIXED LINEAGE LEUKEMIA
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Mixed-lineage leukemia with t(10;11)(p13;q21): an analysis of AF10-CALM and CALM-AF10 fusion mRNAs and clinical features.
|
10221337 |
1999 |
|
M5b Acute differentiated monocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Monocytic leukemia with CALM/AF10 rearrangement showing mediastinal emphysema.
|
12555219 |
2003 |
|
Monocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Monocytic leukemias with CALM/AF10 fusion are frequently associated with mediastinal invasion.
|
12555219 |
2003 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CALM-AF10 fusion gene in leukemias: simple and inversion-associated translocation (10;11).
|
11106826 |
2000 |
|
Acute leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
CALM-AF10 mice infected with the MOL4070LTR retrovirus developed acute leukemia, and ligation-mediated polymerase chain reaction was used to identify retroviral insertions at 19 common insertion sites, including Zeb2, Nf1, Mn1, Evi1, Ift57, Mpl, Plag1, Kras, Erg, Vav1, and Gata1.
|
20007546 |
2010 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PICALM, the gene encoding phosphatidylinositol-binding clathrin assembly (picalm) protein, was recently shown to be associated with risk of Alzheimer disease (AD).
|
20838239 |
2010 |
|
Alzheimer disease, familial, type 3
|
0.010 |
Biomarker
|
disease |
BEFREE |
PICALM might play an important role in AD pathology through participating in altering synaptic vesicle cycling or APP endocytosis.
|
20951388 |
2011 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients.
|
21358043 |
2011 |
|
Impaired cognition
|
0.360 |
Biomarker
|
disease |
BEFREE |
PICALM was associated with an earlier age at midpoint of cognitive decline.
|
22952074 |
2012 |
|
Mental deterioration
|
0.330 |
Biomarker
|
phenotype |
BEFREE |
PICALM was associated with an earlier age at midpoint of cognitive decline.
|
22952074 |
2012 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PICALM gene rs3851179 polymorphism contributes to Alzheimer's disease in an Asian population.
|
23572399 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
CALM-AF10 fusion within early T-cell precursor acute lymphoblastic leukemia (21%) did, however, identify a group with a poor prognosis with regards to event-free survival (P=0.04).
|
23831922 |
2013 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
CALM-AF10 therefore identifies a poor prognostic group within sCD3/T-cell receptor negative adult T-cell acute lymphoblastic leukemias and is over-represented within early T-cell precursor acute lymphoblastic leukemias, in which it identifies patients in whom treatment is likely to fail.
|
23831922 |
2013 |
|
Adult T Acute Lymphoblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
CALM-AF10 therefore identifies a poor prognostic group within sCD3/T-cell receptor negative adult T-cell acute lymphoblastic leukemias and is over-represented within early T-cell precursor acute lymphoblastic leukemias, in which it identifies patients in whom treatment is likely to fail.
|
23831922 |
2013 |
|
Acute lymphocytic leukemia
|
0.060 |
Biomarker
|
disease |
BEFREE |
CALM-AF10 therefore identifies a poor prognostic group within sCD3/T-cell receptor negative adult T-cell acute lymphoblastic leukemias and is over-represented within early T-cell precursor acute lymphoblastic leukemias, in which it identifies patients in whom treatment is likely to fail.
|
23831922 |
2013 |