|
Mild cognitive disorder
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
|
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
|
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
BEFREE |
PICALM and CLU are two major risk genes of late-onset Alzheimer's disease (LOAD), and there is strong molecular evidence suggesting their interaction on amyloid-beta deposition, hence finding functional dependency between their risk genotypes may lead to better understanding of their roles in LOAD development and greater clinical utility.
|
27017968 |
2016 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor.
|
28549650 |
2017 |
|
Alcohol or Other Drugs use
|
0.010 |
Biomarker
|
disease |
BEFREE |
CALM ARC + UC outperformed UC on measures of anxiety and substance use at posttreatment and at a 6-month follow-up.
|
29300100 |
2018 |
|
Impaired cognition
|
0.360 |
Biomarker
|
disease |
BEFREE |
PICALM Gene Methylation in Blood of Alzheimer's Disease Patients Is Associated with Cognitive Decline.
|
30040717 |
2018 |
|
Mental deterioration
|
0.330 |
Biomarker
|
phenotype |
BEFREE |
PICALM Gene Methylation in Blood of Alzheimer's Disease Patients Is Associated with Cognitive Decline.
|
30040717 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
A 27-year-old woman was diagnosed with AML with the PICALM-MLLT10 fusion gene.
|
20875875 |
2010 |
|
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
BEFREE |
A few of these novel LOAD candidate genes, namely BIN1, CLU, CR1, EXOC3L2 and PICALM, have shown consistent replication, and are thus credible LOAD susceptibility genes.
|
21132329 |
2011 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
A genome-wide screen for toxicity modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein (PICALM) and other endocytic factors connected to AD whose relationship to Aβ was previously unknown.
|
22033521 |
2011 |
|
Long QT Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A mutation (F142L) affecting only one of the six CALM alleles is associated with long QT syndrome (LQTS) characterized by recurrent cardiac arrests.
|
28158429 |
2017 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
A novel AF10-CALM fusion transcript in gamma/delta-T cell type lymphoblastic lymphoma.
|
17597474 |
2007 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A novel Alzheimer disease locus located near the gene encoding tau protein.
|
25778476 |
2016 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
LHGDN |
A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.
|
12461747 |
2003 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide study (GWAS) identified a single nucleotide polymorphism (SNP) rs3851179 in the 5' to the PICALM gene strongly associated with Alzheimer's disease (AD) in Caucasians.
|
20951388 |
2011 |
|
MIXED LINEAGE LEUKEMIA
|
0.030 |
Biomarker
|
disease |
BEFREE |
A screening method optimized to discover cytotoxic compounds selective for MLL-rearranged leukemia identified CCI-006 as a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias that share common leukemogenic pathways.
|
30670779 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A screening method optimized to discover cytotoxic compounds selective for MLL-rearranged leukemia identified CCI-006 as a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias that share common leukemogenic pathways.
|
30670779 |
2019 |
|
Childhood Leukemia
|
0.080 |
Biomarker
|
disease |
BEFREE |
A screening method optimized to discover cytotoxic compounds selective for MLL-rearranged leukemia identified CCI-006 as a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias that share common leukemogenic pathways.
|
30670779 |
2019 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A total of 91% (10 of 11) of mice with Zeb2 insertions developed B-lineage acute lymphoblastic leukemia, suggesting that Zeb2 activation promotes the transformation of CALM-AF10 hematopoietic precursors toward B-lineage leukemias.
|
20007546 |
2010 |
|
Anxiety Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Adding CALM ARC to UC for patients with comorbid anxiety disorders and substance use disorders is superior to UC alone.
|
29300100 |
2018 |
|
Substance Use Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Adding CALM ARC to UC for patients with comorbid anxiety disorders and substance use disorders is superior to UC alone.
|
29300100 |
2018 |
|
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Additionally, we found that PICALM expression was modestly increased with the rs3851179A AD-protective allele.
|
24618820 |
2014 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
AF10 is a transcription factor that has been implicated in the development of leukemia following chromosomal rearrangements between the AF10 gene and one of at least two other genes, MLL and CALM.
|
23284727 |
2012 |
|
Childhood Leukemia
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
AF10 is a transcription factor that has been implicated in the development of leukemia following chromosomal rearrangements between the AF10 gene and one of at least two other genes, MLL and CALM.
|
23284727 |
2012 |